关键词: 猫哮喘; 嗜酸性粒细胞气道炎; 下呼吸道疾病

Abstract: Feline asthma is an eosinophilic inflammatory disease of the lower respiratory tract caused by allergens.The clinical manifestations are recurrent cough,shortness of breath,and even dyspnea.The pathological mechanism of feline asthma is similar to that of human high-Th2 asthma,with airway hyperreactive changes,high expression of mucin genes,and eosinophil infiltration.At present,there are no accepted diagnostic guidelines for feline asthma.Chronic bronchitis in the differential diagnosis is very similar to its clinical symptoms and imaging manifestations,and should be the focus of clinical diagnosis.Asthma risk of cat in chest X-ray films showed bronchial or bronchial stroma,bronchial lavage visible eosinophil inflammation.Among the new diagnostic methods,exhaled breath condensate analysis and barometric whole body plethysmography are non-invasive diagnostic methods and can be used in cats in the awake state.After the standardization of exhaled breath condensate biomarkers and barometric whole body plethysmography,the two new diagnostic methods are expected to be applied in the clinical practice of pet cats.Clinical commonly used drugs to corticosteroids,use bronchodilator in cat bronchospasm.Among the new treatment options,rush immunotherapy is a new treatment technology that is expected to completely cure asthma by establishing immune tolerance mechanism for allergens and treating from the initial stage of the allergic inflammation cascade.At present,there are few studies on new diagnostic and therapeutic techniques in pet cats,and most of them are used in feline asthma models established in laboratory.More clinical data are still needed before they can be applied to clinical practice in pet cats.

Key words: feline asthma; eosinophilic airway inflammation; lower airway disease