[1] PRPIC J,BAYMAKOVA M.Hepatitis E virus (HEV) infection among humans and animals:Epidemiology,clinical characteristics,treatment,and prevention[J]. Pathogens,2023,12(7):931. [2] PURDY M A,DREXLER J F,MENG X J,et al.ICTV virus taxonomy profile:Hepeviridae 2022[J].Journal of General Virology,2022,103(9):2645-2646. [3] 王金霞,李雯,张云智.戊型肝炎病原学及流行病学研究进展[J].中国热带医学,2018,18(3):277-281. WANG J X,LI W,ZHANG Y Z.Etiological and epidemiological research progress of hepatitis E[J].China Tropical Medicine,2018,18(3):277-281.(in Chinese) [4] 刘小畅,赵婷,赵志梅,等.中国居民病毒性肝炎流行趋势分析[J].浙江预防医学,2018,30(5):433-437. LIU X C,ZHAO T,ZHAO Z M,et al.Incidence and trends of viral hepatitis in China[J].Preventive Medicine,2018,30(5):433-437.(in Chinese) [5] 贡嘎,崔立.戊型肝炎病毒感染检测方法的研究进展[J].畜牧与兽医,2008,40(5):90-93. GONG G,CUI L.Research progress of detection methods for Hepatitis E virus infection[J].Animal Husbandry&Veterinary Medicine,2008,40(5):90-93.(in Chinese) [6] COOK N,AGOSTINO M D,WOOD A,et al.Real-time PCR-based methods for detection of Hepatitis E virus in pork products:A critical review[J].Microorganisms,2022,10(2):428. [7] 卓娜,朱忠武,李静,等.猪源戊型肝炎病毒ORF2蛋白生物信息学分析及真核表达研究[J].中国畜牧兽医,2023,50(5):1959-1970. ZHUO N,ZHU Z W,LI J,et al.Bioinformatics analysis and eukaryotic expression of ORF2 protein of swine Hepatitis E virus[J].China Animal Husbandry&Veterinary Medicine,2023,50(5):1959-1970.(in Chinese) [8] 闫蕾.猪戊型肝炎病毒荧光定量PCR检测方法的建立及盐城地区流行病学调查[D].大庆:黑龙江八一农垦大学,2016. YAN L.Establishment of fluorescent quantitative PCR assay for swine Hepatitis E virus and molecular epidemiology in Yancheng region[D].Daqing:Heilongjiang Bayi Agricultural University,2016.(in Chinese) [9] 李幽幽,龚双燕,李小璟,等.猪戊型肝炎病毒SYBR Green Ⅱ荧光定量RT-PCR检测方法的建立与应用[J].中国人兽共患病学报,2017,33(11):1002-1006. LI Y Y,GONG S Y,LI X J,et al.Development and application of a SYBR Green Ⅱ Real-time RT-PCR for detection of swine Hepatitis E virus[J].Chinese Journal of Zoonoses,2017,33(11):1002-1006.(in Chinese) [10] JOTHIKUMAR N,CROMEANS T L,ROBERTSON B,et al.A broadly reactive one-step Real-time RT-PCR assay for rapid and sensitive detection of Hepatitis E virus[J].Journal of Virological Methods,2006,131(1):65-71. [11] 陈小金,董志珍,赵祥平,等.基因3型猪戊型肝炎病毒荧光定量RT-PCR检测方法的建立[J].中国动物检疫,2016,33(7):72-77. CHEN X J,DONG Z Z,ZHAO X P,et al.Establishment of TaqMan fluorescence quantitative RT-PCR assay for swine Hepatitis E virus detection[J].China Animal Health Inspection,2016,33(7):72-77.(in Chinese) [12] 白怡霖.猪戊型肝炎病毒血清抗体间接ELISA检测方法的建立与应用[D].杨凌:西北农林科技大学,2018. BAI Y L.Development and application of an indirect ELISA for detecting antibodies against swine Hepatitis E virus[D].Yangling:Northwest A&F University,2018.(in Chinese) [13] 袁悦.双抗体夹心ELISA检测猪戊型肝炎病毒抗原方法的建立及流行病学调查[D].长春:吉林大学,2017. YUAN Y.Development of double antibody sandwich ELISA for detection of swine Hepatitis E virus antigen and epidemiological investigation[D].Changchun:Jilin University,2017.(in Chinese) [14] 陈宜阳.猪戊型肝炎病毒抗体阻断ELISA检测方法的建立与应用[D].杨凌:西北农林科技大学,2016. CHEN Y Y.A novel blocking ELISA for detection of antibodies against Hepatitis E virus in domestic pigs[D].Yangling:Northwest A&F University,2016.(in Chinese) [15] WEN J,LU W,MENG J.Establishment of competitive binding assay to detect and differentiate Hepatitis E virus infection[J].Annals of Hepatology,2019,18(4):590-594. [16] 王家英,娄成,李阳,等.猪戊型肝炎病毒(HEV) RT-qRPA检测方法的建立及应用评价[J].中国兽医学报,2020,40(11):2152-2158. WANG J Y,LOU C,LI Y,et al.Evaluation of RT-qRPA method for the detection of swine Hepatitis E virus[J].Chinese Journal of Veterinary Science,2020,40(11):2152-2158.(in Chinese) [17] WANG K,WANG J,ZHOU C,et al.Rapid and direct detection of Hepatitis E virus in raw pork livers by recombinase polymerase amplification assays[J].Frontiers in Cellular and Infection Microbiology,2022,12:958990. [18] 姜瀚集.基于CRISPR技术的食源性致病微生物检测新技术研究[D].北京:军事科学院,2022. JIANG H J.Research on new technology for detection of food-borne pathogenic microorganisms based on CRISPR[D].Beijing:Academy of Military Sciences,2022.(in Chinese) [19] WHO.Hepatitis E[EB/OL].(2023-07-20)[2023-08-10].https://www.who.int/news-room/fact-sheets/detail/hepatitis-e. [20] 疾病预防控制局.2021年全国法定传染病疫情概况[EB/OL].(2022-04-22)[2023-08-10].http://www.nhc.gov.cn/jkj/s3578/202204/4fd88a291d914abf8f7a91f6333567e1.shtml. DISEASE PREVENTION AND CONTROL BUREAU.Overview of the national epidemic of statutory infectious diseases in 2021[EB/OL].(2022-04-22)[2023-08-10].http://www.nhc.gov.cn/jkj/s3578/202204/4fd88a291d914abf8f7a91f6333567e1.shtml.(in Chinese) [21] 疾病预防控制局.2020年全国法定传染病疫情概况[EB/OL].(2021-03-12)[2023-08-10].http://www.nhc.gov.cn/jkj/s3578/202103/f1a448b7df7d4760976fea6d55834966.shtml.. DISEASE PREVENTION AND CONTROL BUREAU.Overview of the national epidemic of statutory infectious diseases in 2020[EB/OL].(2021-03-12)[2023-08-10].http://www.nhc.gov.cn/jkj/s3578/202103/f1a448b7df7d4760976fea6d55834966.shtml.(in Chinese) [22] 马小龙,吴欢,尹冬梅,等.戊型肝炎的药物治疗研究进展[J].齐齐哈尔医学院学报,2022,43(12):1175-1179. MA X L,WU H,YIN D M,et al.Advances in drug therapy of hepatitis E[J].Journal of Qiqihar Medical University,2022,43(12):1175-1179.(in Chinese) [23] MURATA Y,FALSEY A R.Respiratory syncytial virus infection in adults[J].Antiviral Therapy,2007,12(4 Pt B):659-670. [24] KAMAR N,ABRAVANEL F,BEHRENDT P,et al.Ribavirin for Hepatitis E virus infection after organ transplantation:A large European retrospective multicenter study[J].Clinical Infectious Diseases,2020,71(5):1204-1211. [25] DEBING Y,NEYTS J.Antiviral strategies for Hepatitis E virus[J].Antiviral Research,2014,102:106-118. [26] ALRIC L,BONNET D,LAURENT G,et al.Chronic Hepatitis E virus infection:Successful virologic response to pegylated interferon-alpha therapy[J].Annals of Internal Medicine,2010,153(2):135-136. [27] HAAGSMA E B,BRILMAN A R,BERG A P,et al.Treatment of chronic hepatitis E in liver transplant recipients with pegylated interferon alpha-2b[J].Liver Transplant,2010,16(4):474-477. [28] DEBING Y,EMERSOM S U,WANG Y,et al.Ribavirin inhibits in vitro Hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon[J].Antimicrobial Agents and Chemotherapy,2014,58(1):267-273. [29] MANNS M P,WEDEMEYER H,CORNBERG M.Treating viral Hepatitis C:Efficacy,side effects,and complications[J].Gut,2006,55(9):1350-1359. [30] LZOPET J.Pegylated interferon-alpha for treating chronic Hepatitis E virus infection after liver transplantation[J].Clinical Infectious Diseases,2010,50(5):30-33. [31] EASL.Clinical practice guidelines on Hepatitis E virus infection[J].Journal of Hepatology,2018,68(6):1256-1271. [32] ZAPPATERRA F,COSTA S,SUMMA D,et al.Glyceric prodrug of ursodeoxycholic acid (UDCA):Novozym 435-catalyzed synthesis of UDCA-monoglyceride[J].Molecules,2021,26(19):5966. [33] CROSIGNANI A,BATTEZZATI P M,SETCHELL K D,et al.Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis:A dose-response study[J].Hepatology,1991,13(2):339-344. [34] 李阳,刘子荣,张雅敏.术中应用丁二磺酸腺苷蛋氨酸对成人左半肝切除术后残肝功能及再生的影响[J].中华普通外科杂志,2018,33(11):955-957. LI Y,LIU Z R,ZHANG Y M.The effect of intraoperative administration of S-adenosy-methionine on remnant liver function and regeneration after left lobe resection[J].Chinese Journal of General Surgery,2018,33(11):955-957.(in Chinese) [35] 迟冰冰.腺苷蛋氨酸辅助治疗肝衰竭疗效分析[J].中国现代药物应用,2021,15(1):157-158. CHI B B.Analysis of curative effect of adenosylmethionine in adjuvant treatment of liver failure[J].Chinese Journal of Modern Drug Application,2021,15(1):157-158.(in Chinese) [36] 李艳娇,李爽,刘正飞.熊去氧胆酸、丁二磺酸腺苷蛋氨酸联合治疗ICP合并乙型肝炎效果[J].中国计划生育学杂志,2021,29(3):488-491. LI Y J,LI S,LIU Z F.Effects of ursodeoxycholic acid combined with butane disulfonate ademetionine for treating women with intrahepatic chole-stasis of pregnancy and hepatitis B[J].Chinese Journal of Family Planning,2021,29(3):488-491.(in Chinese) [37] 李可军,夏华,娄宪芝.腺苷蛋氨酸联合熊去氧胆酸治疗老年戊型肝炎的临床研究[J].中国热带医学,2010,10(1):17-18. LI K J,XIA H,LOU X Z.Effect of s-adenosylmethionine combined with ursodeoxycholic acid on elderly hepatitis E patients[J].China Tropical Medicine,2010,10(1):17-18.(in Chinese) [38] CAO M,LI X,ZHANG B,et al.The effect of polyene phosphatidyl choline intervention on nonalcoholic steatohepatitis and related mechanism[J]. American Journal of Translational Research,2016,8(5):2325-2330. [39] 杨林.多烯磷脂胆碱合用还原性谷胱甘肽治疗戊型肝炎[J].医药前沿,2015,25:53-54. YANG L.Treatment of hepatitis E with polyene phosphatidylcholine and reduced glutathione[J].Medical Frontier,2015,25:53-54.(in Chinese) [40] LI P,LI Y,WANG Y,et al.Recapitulating Hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids[J].Science Advances,2022,8(3):eabj5908. [41] 冯雨薇,张建军.40例戊型肝炎中医临床特点分析[J].内蒙古中医药,2017,36(19):19-20. FENG Y W,ZHANG J J.Clinical analysis of 40 hepatitis E patients with the characteristics of traditional Chinese medicine[J].Inner Mongolia Journal of Traditional Chinese Medicine,2017,36(19):19-20.(in Chinese) [42] 国家药典委员会.中华人民共和国药典一部[M].北京:中国医药科技出版社,2020. CHINESE PHARMACOPOEIA COMMISSION.Chinese Pharmacopoeia-Part l[M].Beijing:China Medical Science Press,2020.(in Chinese) [43] 卢志刚,刘芸,易继龙.清开灵注射液对自发性蛛网膜下腔出血后脑血管痉挛患者SOCS-3、TNF-α和IL-6的影响[J].中国医院药学杂志,2015,35(2):141-144. LU Z G,LIU Y,YI J L.Effects of Qingkailing on SOCS-3,TNF-α and IL-6 in patients with cerebral vasospasm after spontaneous subarachnoid hemorrhage[J].Chinese Journal of Hospital Pharmacy,2015,35(2):141-144.(in Chinese) [44] 陈皋.清开灵注射液治疗急性戊型病毒性肝炎临床疗效观察[J].海南医学,2007,18(12):18. CHEN G.Clinical study on the acute hepatitis E treated with Qingkailing injection[J].Hainan Medical Journal,2007,18(12):18.(in Chinese) [45] 张奉海,张世强,刘永辉.自拟赤白汤治疗戊型肝炎52例分析[J].实用中医内科杂志,2003,17(2):115. ZHANG F H,ZHANG S Q,LIU Y H. Analysis of 52 cases of hepatitis E treated by self-made Chibai decoction[J].Journal of Practical Traditional Chinese Internal Medicine,2003,17(2):115.(in Chinese) [46] 王继平.茵陈五苓散加减治疗急性戊型肝炎35例临床观察[J].中国民族民间医药,2015,24(12):64-66. WANG J P.Clinical observation on 35 cases of acute hepatitis E treated with modified Yinchen Wuling powder[J].Chinese Journal of Ethnomedicine and Ethnopharmacy,2015,24(12):64-66.(in Chinese) [47] 田素琴.熊去氧胆酸联合祛湿活血汤治疗急性戊型肝炎临床观察[J].中国中医急症,2010,19(3):390-391. TIAN S Q.Clinical observation on treatment of acute hepatitis E with ursodeoxycholic acid combined with Qushi Huoxue decoction[J].Journal of Emergency in Traditional Chinese Medicine,2010,19(3):390-391.(in Chinese) [48] 杨利超,魏芯芯,张传涛,等.中医药治疗淤胆型肝炎研究进展及展望[J].辽宁中医药大学学报,2015,17(9):135-137. YANG L C,WEI X X,ZHANG C T,et al.Clinical research and prospects of traditional Chinese medicine in the treatment of cholestatic hepatitis[J].Journal of Liaoning University of Traditional Chinese Medicine,2015,17(9):135-137.(in Chinese) [49] 甘草酸制剂肝病临床应用专家委员会.甘草酸制剂肝病临床应用专家共识[J].临床肝胆病杂志,2016,32(5):844-852. EXPERT COMMITTEE ON THE CLINICAL APPLICATION OF GLYCYRRHETINIC ACID PREPARATIONS IN LIVER DISEASES.Expert consensus on clinical application of glycyrrhizin preparation in the treatment of liver diseases[J].Journal of Clinical Hepatology,2016,32(5):844-852.(in Chinese) [50] 刘大川.苦黄联合异甘草酸镁治疗戊肝30例疗效观察[J].医药与保健,2014,12:74-75. LIU D C.Observation on curative effect of Kuhuang combined with Magnesium isoglycyrrhizinate in treating 30 cases of hepatitis E[J]. Medicine and Health Care,2014,12:74-75.(in Chinese) [51] 杨浩,金三俊,庞倩,等.白藜芦醇对畜禽常见肝损伤保护机制及应用的研究进展[J].中国畜牧兽医,2020,47(11):3528-3535. YANG H,JIN S J,PANG Q,et al.Research progress on the protective mechanism and application of resveratrol to common liver injury in livestock and poultry[J]. China Animal Husbandry&Veterinary Medicine,2020,47(11):3528-3535.(in Chinese) [52] 王婉如,高雪峰.戊肝疫苗临床研究的新进展[J].中国生物制品学杂志,2020,33(4):470-475. WANG W R,GAO X F.New progress in clinical research on hepatitis E vaccine[J].Chinese Journal of Biologicals,2020,33(4):470-475.(in Chinese) [53] 曹玉锋.戊型肝炎病毒反向遗传学平台的建立及重组亚单位疫苗的研究[D].长春:吉林大学,2019. CAO Y F.Establishment of the reverse genetics platform for Hepatitis E virus and study on HEV recombinant subunit vaccine[D].Changchun:Jilin University,2019.(in Chinese) [54] PURDY M A,MCCAUSTLAND K A,KRAWCZYNSKI K,et al.Preliminary evidence that a trpE-HEV fusion protein protects cynomolgus macaques against challenge with wild-type Hepatitis E virus (HEV)[J].Journal of Medical Virology,1993,41(1):90-94. [55] LI S W,ZHAO Q,WU T,et al.The development of a recombinant hepatitis E vaccine HEV 239[J].Human Vaccines&Immunotherapeutics,2015,11(4):908-914. [56] WU T,LI S W,ZHANG J,et al.Hepatitis E vaccine development:A 14 year odyssey[J].Human Vaccines&Immunotherapeutics,2012,8(6):823-827. [57] PERON J M,LARRUE H,IZOPET J,et al.The pressing need for a global HEV vaccine[J].Journal of Hepatology, 2023,79(3):876-880. [58] MENG J,DAI X,CHANG J C,et al.Identification and characterization of the neutralization epitope (s) of the Hepatitis E virus[J].Virology,2001,288(2):203-211. [59] WEN J,BEHLOUL N,DAI X,et al.Immunogenicity difference between two hepatitis E vaccines derived from genotype 1 and 4[J].Antiviral Research,2016,128:36-42. [60] SEHGAL D,MALIK P S,JAMEEL S,Purification and diagnostic utility of a recombinant Hepatitis E virus capsid protein expressed in insect larvae[J].Protein Expression and Purification,2003,27(1):27-34. [61] QI Y,FAN J,HUANG W,et al.Expression and characterization of Hepatitis E virus-like particles and non-virus-like particles from insect cells[J].Biotechnology and Applied Biochemistry,2016,63(3):362-3370. [62] 苏彩霞,顾美荣,张萍,等.戊型肝炎病毒Ⅳ型ORF2蛋白在汉逊酵母中的表达[J].生物工程学报,2007,23(1):73-78. SU C X,GU M R,ZHANG P,et al.Expression of ORF2 protein of HEV genotype Ⅳ in Hansenula polymorpha[J].Chinese Journal of Biotechnology,2007,23(1):73-78.(in Chinese) [63] GUPTA J,KUMAR A,SURJIT M.Production of a hepatitis E vaccine candidate using the Pichia pastoris expression system[J].Methods in Molecular Biology,2022,2412:117-141. [64] HONG Y,RUAN B,YANG L H,et al.Hepatitis E virus chimeric DNA vaccine elicits immunologic response in mice[J].World Journal of Gastroenterology,2005,11(42):6713-6715. [65] DESHMUKH T M,LOLE K S,TRIPATHY A S,et al.Immunogenicity of candidate Hepatitis E virus DNA vaccine expressing complete and truncated ORF2 in mice[J].Vaccine,2007,25(22):4350-4360. [66] FARSHADPOUR F,MAKVANDI M,TAHERKHANI R.Design,construction and cloning of truncated ORF2 and tPAsp-PADRE-Truncated ORF2 gene cassette from Hepatitis E virus in the pVAX1 expression vector[J].Jundishapur Journal of Microbiology,2015,8(12):e26035. [67] XIANG K,KUSOV Y,YING G,et al.A recombinant HAV expressing a neutralization epitope of HEV induces immune response against HAV and HEV in mice[J].Viruses,2017,9(9):260. [68] GAO Y,SU Q,YI Y,et al.Enhanced mucosal immune responses induced by a combined candidate mucosal vaccine based on Hepatitis A virus and Hepatitis E virus structural proteins linked to tuftsin[J]. Public Library of Science,2015,10(4):e0123400. [69] LI H Z,GANG H Y,SUN Q M,et al.Production in Pichia pastoris and characterization of genetic engineered chimeric HBV/HEV virus-like particles[J]. Chinese Medical Sciences Journal,2004,19(2):78-83. [70] WANG L,CAO D,WEI C,et al.A dual vaccine candidate against norovirus and Hepatitis E virus[J].Vaccine,2014,32(4):445-452. [71] LI T C,SUZAKI Y,AMI Y,et al.Protection of cynomolgus monkeys against HEV infection by oral administration of recombinant Hepatitis E virus-like particles[J]. Vaccine,2004,22(3-4):370-377. [72] 魏文娟.重组戊型肝炎口服疫苗的设计与免疫原性研究[D].南京:东南大学,2020. WEI W J.Design and immunogenicity study of oral recombinant hepatitis E vaccine[D].Nanjing:Southeast University,2020.(in Chinese) [73] ZAHMANOVA G,TAKOVA K,VALKOVA R,et al.Plant-derived recombinant vaccines against zoonotic viruses[J].Life (Basel),2022,12(2):156. [74] SARRA B.戊型肝炎-猪圆环病毒病基因工程嵌合疫苗的设计和基础研究[D].南京:东南大学,2021. SARRA B.Design and development of chimeric vaccine candidates against hepatitis E and Porcine circovirus-associated disease[D].Nanjing:Southeast University,2021.(in Chinese) [75] 韩冰,汤思淇,朱大帷,等.新型疫苗佐剂研究进展[J].中国畜牧兽医,2023,50(6):2460-2467. HAN B,TANG S Q,ZHU D W,et al.Research progress of novel vaccine adjuvants[J]. China Animal Husbandry&Veterinary Medicine,2023,50(6):2460-2467.(in Chinese) |