中国畜牧兽医 ›› 2023, Vol. 50 ›› Issue (5): 2114-2129.doi: 10.16431/j.cnki.1671-7236.2023.05.038
陈天宝1,2, 王娅妮1, 刘宝玲1, 王刚1, 王晓虎1, 柳旭辉3, 蔡汝健1, 贺东生2
收稿日期:2022-11-16
出版日期:2023-05-05
发布日期:2023-04-28
通讯作者:
蔡汝健, 贺东生
E-mail:466866569@qq.com;dhe@scau.edu.cn
作者简介:陈天宝,E-mail:924251515@qq.com。
基金资助:CHEN Tianbao1,2, WANG Yani1, LIU Baoling1, WANG Gang1, WANG Xiaohu1, LIU Xuhui3, CAI Rujian1, HE Dongsheng2
Received:2022-11-16
Online:2023-05-05
Published:2023-04-28
摘要： 猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)是由猪繁殖与呼吸综合征病毒(Porcine reproductive and respiratory syndrome virus,PRRSV)引起的烈性、高度接触性传染病,主要引起母猪繁殖障碍和仔猪呼吸道症状。疫苗免疫是防控PRRS的主要手段,但由于PRRSV毒株高度变异性导致疫苗对该病的效果仍不理想。中药(traditional Chinese medicine,TCM)活性成分众多,生理活性多样,包括抗菌、抗病毒和抗氧化等作用,是抗病毒药物的研究热点。研究证明,中药能以单体或复方的方式对PRRSV产生抑制增殖、阻断吸附和杀灭病毒的作用,以及对机体免疫反应产生影响。关于中药抗PRRSV的机制包括直接抗病毒机制和间接抗病毒机制。直接抗病毒机制即中药有效成分对病毒复制周期的直接影响,主要表现为抑制病毒的吸附、内化、复制、大分子组装和释放中的一环,从而达到抑制病毒的作用。间接抗病毒机制即中药有效成分通过调节细胞因子合成、炎症信号通路、细胞凋亡、氧化代谢和免疫系统等途径来抑制病毒对宿主细胞的负面影响,保证机体免疫反应产生的同时减少机体的损伤。由于中药成分复杂,且抗PRRSV机制尚不明确,因此,笔者以抗病毒作用机制为依据对近年来中药抗PRRSV的研究进行综述,以期为中药防控PRRSV提供理论依据。
中图分类号:
陈天宝, 王娅妮, 刘宝玲, 王刚, 王晓虎, 柳旭辉, 蔡汝健, 贺东生. 中药抗猪繁殖与呼吸综合征病毒的作用机制研究进展[J]. 中国畜牧兽医, 2023, 50(5): 2114-2129.
CHEN Tianbao, WANG Yani, LIU Baoling, WANG Gang, WANG Xiaohu, LIU Xuhui, CAI Rujian, HE Dongsheng. Research Progress on the Anti-Porcine Reproductive and Respiratory Syndrome Virus Effect and Mechanism of Traditional Chinese Medicine[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2114-2129.
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