脂质体递药系统设计思路及其兽药应用研究进展

doi:10.16431/j.cnki.1671-7236.2016.07.034

摘要/Abstract

摘要：

脂质体作为一种优良的药物载体，具有载药范围广、高效、低毒等特点，能增加包载药物的稳定性和溶解度，赋予药物靶向和缓释的递药特性，并能有效提高药物的生物利用度，是近年来多领域研究和应用的热点。作者从脂质体的结构、粒径设计及制备方法筛选层面总结脂质体的构建思路，结合兽药应用特点和用药需求归纳脂质体递药系统在兽药领域的研究进展，以期为新型递药系统在兽药领域的研发应用提供参考。

关键词: 脂质体; 递药系统; 粒径设计; 兽药

Abstract:

As an excellent pharmaceutical carrier,liposomes exhibit characteristics of wide drug loading range,high efficiency and low toxicity.Besides increasing stability and solubility of loading drugs,liposomes can ascribe targeting and sustained release features to loading drugs.Meanwhile,it can improve bioavailability of loading drugs.Based on the above characteristics,liposomes is becoming hot spot of research and application.This article reviewed construction methods of liposomes based on structure,particle design and chosen of preparation method.Combined with application and demands of veterinary medicine,research progress on application of liposome in the field of veterinary medicine was submitted.It is expected that this article will provide reference for the development of new drug delivery systems used in the field of veterinary medicine.

Key words: liposomes; drug delivery system; particle design; veterinary medicine

中图分类号:

S853.7

林珈好, 董军, 李格宾, 林德贵. 脂质体递药系统设计思路及其兽药应用研究进展[J]. 《中国畜牧兽医》---唯一指定的官方网站, 2016, 43(7): 1884-1889.

LIN Jia-hao, DONG Jun, LI Ge-bin, LIN De-gui. Research Process on Design of Liposomes as Drug Delivery System and Its Application in the Field of Veterinary Medicine[J]. , 2016, 43(7): 1884-1889.

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