中兽药复方组合与抗生素防治肉鸡呼吸道疾病的协同效应

doi:10.16431/j.cnki.1671-7236.2020.03.034

摘要/Abstract

摘要： 为探讨中兽药复方组合与抗生素防治肉鸡呼吸道疾病的协同效应，本研究在规模化鸡场两栋鸡舍内分别随机选取100只3日龄白羽肉鸡，分为两组（Ⅰ组和Ⅱ组）：Ⅰ组饮水添加抗生素，Ⅱ组在添加抗生素基础上的不同阶段分别饲喂中兽药玉屏风口服液（3~7 d）、射干地龙颗粒（10~16 d）、双黄连口服液（22~25 d）、麻杏石甘口服液（27~31 d）。分别于8日龄免疫鸡传染性支气管炎活疫苗、新城疫-传染性支气管炎二联活疫苗和新城疫-禽流感二联灭活疫苗，免疫后1、7、14、21、28 d采集血清和气管组织，检测新城疫、禽流感（H9）、传染性支气管炎疫苗的抗体水平，观察气管组织病理变化，计算免疫器官指数和平均日增重。结果显示，Ⅱ组的成活率较Ⅰ组提高了1.23%，Ⅱ组末体重与平均日增重极显著高于Ⅰ组（P<0.01），分别提高了561.25和16.63 g/d；Ⅱ组病鸡呼吸道症状较Ⅰ组轻，病程短，肝脏和心脏无明显病变，脾脏指数在36 d显著高于Ⅰ组（P<0.05）。免疫后21 d，Ⅱ组新城疫、传染性支气管炎和禽流感（H9）疫苗的抗体水平达到最高，显著高于Ⅰ组（P<0.05）；免疫后28 d，Ⅱ组新城疫抗体水平极显著高于Ⅰ组（P<0.01）。综上所述，4种清热解毒、止咳平喘、清肝利胆的中兽药复方组合使用与抗生素促生长和预防肉鸡呼吸道疾病具有协同效应。

关键词: 中兽药复方; 气管组织; 抗生素; 白羽肉鸡

Abstract: In order to explore the synergistic effect of the combination of Chinese veterinary drugs and antibiotics on the prevention and treatment of respiratory diseases in broilers,100 three-day-old White-feather broilers were randomly selected from two chicken houses in large-scale chicken farms,which were divided into two groups (group Ⅰ and group Ⅱ).Group Ⅰ was given antibiotics in drinking water.Group Ⅱ was fed with Chinese veterinary drug Yupingfeng oral liquid (3-7 d),Shegan Dilong granule (10-16 d),Shuanghuanglian oral liquid (22-25 d),Maxingshigan oral liquid (27-31 d) in different stages on the basis of adding antibiotics.Chicken infectious bronchitis live vaccine,Newcastle disease-infectious bronchitis combined live vaccine and Newcastle disease-avian influenza two inactivated vaccine were vaccinated at 8-day-old.Serum and tracheal tissues were collected at 1,7,14,21 and 28 days after immunization to detect antibody levels of Newcastle disease,avian influenza (H9),and infectious bronchitis vaccines,observe pathological changes of tracheal tissues,and calculate the immune organ index and average daily gain,and record the incidence rate.The results showed that the survival rate of group Ⅱ increased by 1.23% compared with group Ⅰ.The final weight and average daily weight of group Ⅱ were extremely significantly higher than that of group Ⅰ (P<0.01),which increased by 561.25 g and 16.63 g/d,respectively.The respiratory symptoms of group Ⅱ were lighter than that of group Ⅰ,the course of disease was short,and there were no obvious lesions in liver and heart.The spleen index was significantly higher than that of group Ⅰ at 36 d (P<0.05).At 21 days after immunization,the antibody levels of Newcastle disease,infectious bronchitis and avian influenza (H9) vaccine in group Ⅱ reached the highest level,which was significantly higher than group Ⅰ (P<0.05).The level of Newcastle disease antibody in group Ⅱ was extremely significantly higher than that of group Ⅰ(P<0.01) at 28 days after immunization.In summary,the combination of four kinds of Chinese veterinary drugs,which clearing heat-toxin,relieving cough and asthma,clearing liver and gallbladder,combined with antibiotic had synergistic effect on promoting growth and prevention of respiratory diseases in broilers.

Key words: Chinese veterinary medicine compounds; tracheal tissue; antibiotics; White-feather broiler

中图分类号:

S858.31

冯海鹏, 辛蕊华, 张凯, 王磊, 张康, 李建喜, 王学智. 中兽药复方组合与抗生素防治肉鸡呼吸道疾病的协同效应[J]. 中国畜牧兽医, 2020, 47(3): 940-947.

FENG Haipeng, XIN Ruihua, ZHANG Kai, WANG Lei, ZHANG Kang, LI Jianxi, WANG Xuezhi. Synergistic Effect of Combination of Chinese Veterinary Drugs and Antibiotics on the Prevention and Treatment of Respiratory Diseases in Broilers[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(3): 940-947.

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