无乳链球菌毒力基因与耐药性的相关性研究进展

doi:10.16431/j.cnki.1671-7236.2021.01.041

中国畜牧兽医 ›› 2021, Vol. 48 ›› Issue (1): 375-384.doi: 10.16431/j.cnki.1671-7236.2021.01.041

无乳链球菌毒力基因与耐药性的相关性研究进展

范雪^1,2, 邵伟¹, 赵艳坤², 杜晓慧¹, 陈贺², 王富兰²

1. 新疆农业大学动物科学学院, 新疆肉乳用草食动物营养实验室, 乌鲁木齐 830052;
2. 新疆农业科学院农业质量标准与检测技术研究所, 农业农村部农产品质量安全风险评估实验室新疆农产品质量安全实验室, 乌鲁木齐 830091

收稿日期:2020-07-02 出版日期:2021-01-20 发布日期:2021-01-15
通讯作者: 赵艳坤 E-mail:yankunzhao90@163.com
作者简介:范雪(1995-),女,新疆奇台人,硕士生,研究方向:动物生产,E-mail:fanxue1205@163.com
基金资助:
新疆维吾尔自治区自然科学基金（2019D01B32）；自治区公益性科研院所基本科研业务经费资助项目（KY2019031）；自治区重点实验室开放课题（2018D04016）；自治区天山青年计划（2018Q087）；国家农产品质量安全风险评估重大专项（GJFP2019027）；农业农村部奶及奶制品质量安全控制重点实验室开放课题（2018KLMDP002）；新疆维吾尔自治区研究生创新项目（XJ2020G158）

Research Progress on the Correlation Between Virulence Genes and Drug Resistance of Streptococcus agalactiae

FAN Xue^1,2, SHAO Wei¹, ZHAO Yankun², DU Xiaohui¹, CHEN He², WANG Fulan²

1. Xinjiang Key Laboratory of Meat Milk Production Herbivore Nutrition, College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China;
2. Key Laboratory of Agro-Products Quality and Safety of Xinjiang, Ministry of Agriculture and Rural Affairs Laboratory of Quality and Safety Risk Assessment for Agro-products, Institute of Quality Standard and Testing Technology for Agro-Products, Xinjiang Academy of Agriculture Science, Urumqi 830091, China

Received:2020-07-02 Online:2021-01-20 Published:2021-01-15

摘要/Abstract

摘要： 乳房炎是奶牛养殖业中最常见的一种疾病，会造成奶牛乳腺发炎肿胀，使产奶量大幅下降。作为一种多因素性疾病，奶牛乳房炎发病原因复杂，饲料污染、病原菌感染以及环境因素均可以导致乳房炎的发生。无乳链球菌（Streptococcus agalactiae）作为奶牛乳房炎的主要致病菌，常会造成乳腺组织的局部炎症，随着无乳链球菌分离率的增加以及抗菌药物的滥用，其对抗菌药物的耐药性逐步攀升，给临床治疗带来了一定的困难。此外，无乳链球菌能够定植于宿主体内，破坏宿主的免疫系统，而其自身毒力因子会引起宿主机体疾病的产生。随着相关研究的深入，发现毒力与耐药性本身互为关联，耐药性的增强以不同的方式影响毒力，表明了耐药性与毒力因子之间存在着一定的相关性。笔者主要回顾了国内外链球菌以及其他细菌毒力基因与耐药性之间相关性的研究进展，从无乳链球菌毒力因子及耐药性等多种角度入手，分析了无乳链球菌的毒力机制以及毒力基因，并对近5年国内不同地区无乳链球菌耐药性进行统计，从细菌种类、环境和相关机制对链球菌的毒力和耐药性之间的关系展开综述，以期为无乳链球菌所引起的临床症状筛选出合理的抗菌药物并对毒力基因与耐药性的相关性研究提供理论参考。

关键词: 无乳链球菌; 毒力因子; 耐药性; 机制; 抗生素

Abstract: Mastitis,which is the most common disease in dairy cows production,can cause inflammation and swelling in the mammary glands of cows,and significantly reduce the milk production.As a multi-factor disease,the reason for mastitis is very complicated.Mastitis is mainly affected by feed contamination,pathogenic bacteria infection,and environmental factors.As the main pathogenic bacteria of mastitis,Streptococcus agalactiae often induces local inflammation of breast tissue.With the increase of the separation rate of Streptococcus agalactiae and the abuse of antibacterial drugs,the resistance of Streptococcus agalactiae to antibacterial drugs gradually increases,which brings certain difficulties to clinical treatment.Additionally,Streptococcus agalactiae can colonize the host,and then damage the immune system of host,and its own virulence factors also can cause disease of host body.With the deepening of relevant researches,it has found that virulence and drug resistance are interrelated with each other.The virulence is affected by the increased drug resistance with different ways,indicating that there is a certain correlation between drug resistance and virulence factors.The authors reviewed research progress of the correlation between Streptococcus and other bacterial virulence genes and drug resistance at home and abroad.The virulence mechanism and virulence genes of Streptococcus agalactiae were analyzed from the perspectives of virulence factors and drug resistance.Besides,the drug resistance of Streptococcus agalactiae in different regions in the past 5 years was recorded.The relationship between Streptococcus virulence and drug resistance was reviewed from the perspectives of bacterial species,environment,and related mechanism,so as to provide theoretical reference for the reasonable selection of antibacterial agents for clinical symptoms induced by Streptococcus agalactiae and relevant researches of virulence genes and drug resistance.

Key words: Streptococcus agalactiae; virulence factor; drug resistance; mechanism; antibiotic

中图分类号:

S815

范雪, 邵伟, 赵艳坤, 杜晓慧, 陈贺, 王富兰. 无乳链球菌毒力基因与耐药性的相关性研究进展[J]. 中国畜牧兽医, 2021, 48(1): 375-384.

FAN Xue, SHAO Wei, ZHAO Yankun, DU Xiaohui, CHEN He, WANG Fulan. Research Progress on the Correlation Between Virulence Genes and Drug Resistance of Streptococcus agalactiae[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 375-384.

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无乳链球菌毒力基因与耐药性的相关性研究进展

Research Progress on the Correlation Between Virulence Genes and Drug Resistance of Streptococcus agalactiae

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