[1] 国家药典委员会. 中华人民共和国兽药典(2015版)[M]. 北京: 中国医药科技出版社, 2015. NATIONAL PHARMACOPOEIA COMMISSION. Veterinary Drug Code of the People's Republic of China (2015th ed. )[M]. Beijing: China Medical Science Press, 2015. (in Chinese) [2] KOVALAKOVA P, CIZMAS L, MARSALEK B, et al. Occurrence and toxicity of antibiotics in the aquatic environment: A review[J]. Chemosphere, 2020, 251: 126351. [3] 李永琴, 刘宁, 陈娟, 等. 宁夏地区畜禽产品兽药残留监控现状分析[J]. 宁夏农林科技, 2019, 60(2): 27-29. LI Y Q, LIU N, CHEN J, et al. Veterinary drug residues monitoring in domestic animal products in Ningxia[J]. Ningxia Journal of Agriculture and Forestry Science and Technology, 2019, 60(2): 27-29. (in Chinese) [4] BOULANGER B, VARGO J D, SCHNOOR J L, et al. Evaluation of perfluorooctane surfactants in a wastewater treatment system and in a commercial surface protection product[J]. Environmental Science & Technology, 2005, 39(15): 5524-5530. [5] GOULAS A, BELHAD D, DESCAMPS A, et al. How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review[J]. Environmental Evidence, 2020, 9(1): 310-317. [6] GONZÁLEZ-PLEITER M, GONZALO S, RODEA-PALOMARES I, et al. Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: Implications for environmental risk assessment[J]. Water Research, 2013, 47(6): 2050-2064. [7] MAGDALENO A, SAENZ M E, JUÁREZ A B, et al. Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata[J]. Ecotoxicology and Environmental Safety, 2015, 113: 72-78. [8] 王桂祥, 张琼, 匡少平, 等. 环境浓度下的混合抗生素对普通小球藻的联合毒性[J]. 生态毒理学报, 2019, 14(2): 122-128. WANG G X, ZHANG Q, KUANG S P, et al. The joint toxicity of mixed antibiotics on Chlorella vulgaris at normal environmental concentration[J]. Asian Journal of Ecotoxicology, 2019, 14(2): 122-128. (in Chinese) [9] MUNCH C A, FLEMMING I, ANDERS B. Ecotoxicity of mixtures of antibiotics used in aquacultures[J]. Environmental Toxicology and Chemistry, 2006, 25(8): 2208-2215. [10] 徐向月, 马文瑾, 安博宇, 等. 四环素类抗生素在环境中的风险评估研究进展[J]. 中国畜牧兽医, 2020, 47(3): 948-957. XU X Y, MA W J, AN B Y, et al. Advances on risk assessment of tetracycline antibiotics in the environment[J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(3): 948-957. (in Chinese) [11] VICENTE E, VILLAR R, PEREZ-SILANES S, et al. Quinoxaline 1, 4-Di-N-oxide and the potential for treating tuberculosis[J]. Infectious Disorders-Drug Targets, 2011, 11(2): 196-204. [12] 王猛超, 刘树深, 陈浮. 拓展浓度加和模型预测三种三嗪类除草剂混合物的时间依赖毒性[J]. 化学学报, 2014, 72(1): 56-60. WANG M C, LIU S S, CHEN F. Predicting the time-dependent toxicities of three triazine herbicide mixtures to V. qinghaiensis sp. Q67 using the extended concentration addition model[J]. Acta Chimica Sinica, 2014, 72(1): 56-60. (in Chinese) [13] WEI S, WANG F, CHEN Y, et al. The joint toxicity effect of five antibiotics and dibutyl phthalate to luminescent bacteria (Vibrio fischeri)[J]. Environmental Science and Pollution Research, 2018, 25(26): 26504-26511. [14] LIU Z Y, SUN Z L. The metabolism of carbadox, olaquindox, mequindox, quinocetone, and cyadox: An overview[J]. Medicinal Chemistry, 2013, 9(8): 1017-1027. [15] 魏志强. 喹烯酮体外细胞毒性研究进展[J]. 继续医学教育, 2016, 30(4): 155-156. WEI Z Q. Research progress on in vitro cytotoxicity of quinolinone[J]. Continuing Medical Education, 2016, 30(4): 155-156. (in Chinese) [16] CHEN Q, TANG S S, JIN X, et al. Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells[J]. Food and Chemical Toxicology, 2009, 47(2): 328-334. [17] HE J, FIGUEROA D A, LIM T P, et al. Stability of polymyxin B sulfate diluted in 0.9% sodium chloride injection and stored at 4 or 25 ℃[J]. American Journal of Health-System Pharmacy, 2010, 67(14): 1191-1194. [18] XU Y Q, LI K, WANG Z J, et al. The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp. -Q67[J]. Environmental Sciences Europe, 2020, 32(10): 527-533. [19] 杨小虎. 硫酸多粘菌素B分离纯化工艺研究[D]. 杭州: 浙江大学, 2020. YANG X H. The study of polymyxin B sulfate on the separation and purification[D]. Hangzhou: Zhejiang University, 2020. (in Chinese) [20] 于润林, 崔舒云, 程波, 等. 两种剂量下恩诺沙星及其代谢物环丙沙星在虹鳟鱼体内代谢残留研究[J]. 大连海洋大学学报, 2021, 6: 985-994. YU R L, CUI S Y, CHENG B, et al. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in rainbow trout Oncorhynchus mykiss at two doses after oral administration[J]. Journal of Dalian Ocean University, 2021, 6: 985-994. (in Chinese) [21] HASSAN M M, EL ZOWALATY M E, LUNDKVIST Å, et al. Residual antimicrobial agents in food originating from animals[J]. Trends in Food Science & Technology, 2021, 111: 141-150. [22] ZOU S C, XU W H, ZHANG R J, et al. Occurrence and distribution of antibiotics in coastal water of the Bohai Bay, China: Impacts of river discharge and aquaculture activities[J]. Environmental Pollution, 2011, 159(10): 2913-2920. [23] HAN Y, ZHOU W S, TANG Y, et al. Microplastics aggravate the bioaccumulation of three veterinary antibiotics in the thick shell mussel Mytilus coruscus and induce synergistic immunotoxic effects[J]. Science of the Total Environment, 2021, 770: 145273. [24] KRISHAN M, KRETSER A. Toxicology and risk assessment of chemical mixtures[J]. Toxicology Letters, 2014, 229: S219. [25] HOU L R, LIU F, ZHAO C, et al. Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway[J]. Toxicology Mechanisms and Methods, 2021, 4: 21-23 [26] 胡瑶琪, 侯力睿, 傅榆涵, 等. 环丙沙星和恩诺沙星联合肝毒性及其机制研究[J]. 中国兽医科学, 2021, 51(4): 509-517. HU Y Q, HOU L R, FU Y H, et al. Synergistic hepatotoxicity and mechanism induced by ciprofloxacin and enrofloxacin[J]. Chinese Veterinary Science, 2021, 51(4): 509-517. (in Chinese) [27] DU R J, CHEN P, ZHZANG Q X, et al. The degradation of enrofloxacin by a non-metallic heptazine-based OCN polymer: Kinetics, mechanism and effect of water constituents[J]. Chemosphere, 2021, 273: 128435. [28] SHEN W F, LOU B, XU C, et al. Lethal toxicity and gene expression changes in embryonic zebrafish upon exposure to individual and mixture of malathion, chlorpyrifos and lambda-cyhalothrin[J]. Chemosphere, 2020, 239: 124802. [29] 于瑞莲, 林喜燕, 胡恭任. 酚类化合物对发光菌的联合毒性[J]. 华侨大学学报(自然科学版), 2009, 30(5): 549-552. YU R L, LIN X Y, HU G R. The joint toxicity of phenols to photobacterium phosphoreum[J]. Journal of Huaqiao University (Natural Science), 2009, 30(5): 549-552. (in Chinese) [30] 连勇, 周炯林, 徐培渝. 敌敌畏、乐果和马拉硫磷单独及两两联合诱导HepG2细胞DNA损伤的实验研究[J]. 癌变·畸变·突变, 2010, 22(2): 126-129. LIAN Y, ZHOU J L, XU P Y. DNA damage induced by three organophosphate pesticides[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(2): 126-129. (in Chinese) [31] FENG L, LI K, TANG H X, et al. The time-dependent synergism of the six-component mixtures of substituted phenols, pesticides and ionic liquids to Caenorhabditis elegans[J]. Journal of Hazardous Materials, 2017, 327: 11-17. [32] ZOU X M, LIN Z F, DENG Z Q, et al. The joint effects of sulfonamides and their potentiator on Photobacterium phosphoreum: Differences between the acute and chronic mixture toxicity mechanisms[J]. Chemosphere, 2012, 86(1): 30-35. [33] SUN H Y, PAN Y Z, CHEN X, et al. Regular time-dependent cross-phenomena induced by hormesis: A case study of binary antibacterial mixtures to Aliivibrio fischeri[J]. Ecotoxicology and Environmental Safety, 2020, 187: 109823. [34] OJO A F, CHENG P, NG J C. Combined effects and toxicological interactions of perfluoroalkyl and polyfluoroalkyl substances mixtures in human liver cells (HepG2)[J]. Environmental Pollution, 2020, 263(Pt B): 114182. |