miRNA对乳腺发育及泌乳调节作用的研究进展

doi:10.11843/j.issn.1671-7236.2015.03.024

《中国畜牧兽医》---唯一指定的官方网站 ›› 2015, Vol. 42 ›› Issue (3): 663-667.doi: 10.11843/j.issn.1671-7236.2015.03.024

miRNA对乳腺发育及泌乳调节作用的研究进展

张抒¹, 张强², 张萌¹, 杨建成¹

1. 沈阳农业大学畜牧兽医学院, 沈阳 110161;
2. 沈阳市畜牧兽医局, 沈阳 110014

收稿日期:2014-08-26 出版日期:2015-03-20 发布日期:2015-03-30
通讯作者: 杨建成 E-mail:syauyjc@126.com
作者简介:张抒(1989-),女,辽宁沈阳人,硕士,研究方向:生殖与内分泌,E-mail:1989zhangshu@sina.cn
基金资助:
辽宁省高等学校杰出青年学者成长计划(LJQ2014073);沈阳农业大学天柱山英才支持计划

Research Progress on Regulation Effect of microRNA on Mammary Gland Development and Lactation

ZHANG Shu¹, ZHANG Qiang², ZHANG Meng¹, YANG Jian-cheng¹

1. Institute of Animal Husbandry Veterinary, Shenyang Agricultural University, Shenyang 110161, China;
2. Animal Husbandry and Veterinary Bureau of Shenyang City, Shenyang 110014, China

Received:2014-08-26 Online:2015-03-20 Published:2015-03-30

摘要/Abstract

摘要： microRNA(miRNA)是一类在转录后调节基因表达的非编码RNA,已有大量研究表明,miRNA参与多种生命活动的调节,包括细胞增殖与分化、激素分泌、新陈代谢、肌肉和脂肪的形成发育、免疫应答反应、疾病的发生和肿瘤的形成等.近年来miRNA已成为生命科学研究中的亮点.随着miRNA的发现及其功能研究的深入,有关乳腺生长发育和泌乳调控的研究也进入了miRNA调控的新层面.文章总结了乳腺发育和泌乳过程中miRNA表达的阶段特异性及健康乳腺和乳腺病变时miRNA的差异表达,综述了miRNA对乳腺发育和泌乳的调节作用,旨在为从miRNA层面研究乳腺发育及泌乳提供新思路.

关键词: miRNA; 乳腺发育; 泌乳

Abstract: microRNAs (miRNAs) are non-coding RNAs that play important roles in post transcriptional regulation of gene expression,there are a large number of studies have shown that,miRNA involved in regulating a variety of life activities,including the formation of cell proliferation and differentiation,hormone secretion,metabolism,the formation and development of muscle and fat,immune response,and tumor formation and other diseases.In recent years,miRNA has become a bright spot in the life science research.With the discovery of miRNA and its functional study in-depth,the relevant research of breast growth and lactation regulation has entered a new level of miRNA regulation.This article summarizes the miRNA stage-specific expression in mammary gland development and lactation process and differences in health breast and breast lesions when miRNA expression,reviewed the regulation effect of miRNA on mammary gland development and lactation,for the purpose of providing new ideas from the miRNA level on mammary development and lactation.

Key words: miRNA; mammary gland development; lactation

中图分类号:

Q522

张抒, 张强, 张萌, 杨建成. miRNA对乳腺发育及泌乳调节作用的研究进展[J]. 《中国畜牧兽医》---唯一指定的官方网站, 2015, 42(3): 663-667.

ZHANG Shu, ZHANG Qiang, ZHANG Meng, YANG Jian-cheng. Research Progress on Regulation Effect of microRNA on Mammary Gland Development and Lactation[J]. , 2015, 42(3): 663-667.

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miRNA对乳腺发育及泌乳调节作用的研究进展

Research Progress on Regulation Effect of microRNA on Mammary Gland Development and Lactation

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