牛朊蛋白基因多态性对疯牛病影响的研究进展

Abstract

Abstract: The prion protein is the pathogenesis agent for transmissible spongiform encephlopathies (TSE) of human being and some mammal. The polymorphisms of the prion protein (PRNP)gene were significantly affect the susceptibility or resistance to TSE for human being and mammal. In this paper, we analyzed the origins, the monitoring and prevention of BSE. The structure and function of PRNP gene in cattle were introduced briefly.The polymorphism of bovine PRNP gene locating in non-coding region was analyzed systematically. We also summarized and compared the insertion-deletion (indel) in the promoter (23 bp) and the first intron (12 bp) polymorphism together for BSE susceptibility. These could assist the cattle molecular breeding project.

Key words: bovine spongiform encephalopathies (BSE); prion protein gene (PRNP); polymorphisms; resisitance

CLC Number:

S858.23

CHEN Ting, LIU Wan-hong, YANG Chun-ling, LI Qiang-fei, HAO Tian-tian, XI Dong-mei. Research Progress on Effect of Polymorphisms of the Prion protein Gene on Bovine Spongiform Encephalopathies[J]. , 2013, (5): 150-155.

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Research Progress on Effect of Polymorphisms of the Prion protein Gene on Bovine Spongiform Encephalopathies

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