›› 2010, Vol. 37 ›› Issue (2): 159-161.

• 疾病防治 • Previous Articles     Next Articles

Study on the Drug Sensitivity Test of Pathogenic Escherichia coliIsolated from Piglet’s Yellow Dysentery and the Cure Effects of Different Drug Administration Ways

TANG Guang-wu1 , WU Yu-cen1, GUO Shuang2 , YAN Ruo-qian3   

  1. (1.Zhengzhou College of Animal Husbandry Engineering, Zhengzhou 450011, China; 2.Henan Agricultural University, Zhengzhou 450002， China; 3.Henan Centre for Animal Disease Control and Prevention, Zhengzhou 450008, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-02-20 Published:2010-02-20

Abstract: Abstract：In order to scientifically evaluate the drug sensitivity of pathogenic Escherichia coli strains isolated from piglit’s yellow dysentery and the cure effects of different drug administrating ways, the pathogenic Escherichia coli(E. coli) strains were first isolated from piglets sickened yellow dysentery in 25 large-scale pig farms from Henan province. The virulence tests were carried out by analyzing pathogenicity of the isolated E. coli strains to mouse. Drug sensitive tests of the isolated bacteria strains on 20 kinds of antibiotics were carried out to estimate the most sensitive antibiotics drugs. Three different ways of drug administrating which including oral administration, intramuscular injection and intraperitoneal injection were tested to evaluate the best drug administration way. The results demonstrated that total 25 strains of E. coli were isolated from 25 sickened pig farms. All the isolated E. coli strains displayed the pathogenicity to mouse with 100% morbidity rate. Drug resistance appeared to each antibacterial drug, but the drug resistance rate was different (from 4% to 100%). Among the 20 antibacterial drugs, Norfloxacin,Floxacin,Neomycin and Rifampicin showed higher drug sensitivity to 25 E. coli isolated strains than the others, which displayed the high sensitivity rates of 92%,88%,88% and 80%, respectively .Three different ways of drug administration exhibited the different therapeutic effects on clinic sickened piglets. The drug administration ways of oral administration and intraperitoneal injection demonstrated higher cure rates (92.3% and 95.0% respectively) than that by drug administrating of intramuscular injection (58.8%）. The oral administration showed slightly higher cure rate than the intraperitoneal injection, which was no significantly statistical difference between them.

Key words: Key words：piglet’s yellow dysentery; Escherichia coli; drug sensitivity test; oral administration; intramuscular injection; intraperitoneal injection; therapeutic effect