牛磺鹅去氧胆酸对免疫抑制小鼠免疫功能的影响

›› 2010, Vol. 37 ›› Issue (5): 57-59.

• 生理生化 • Previous Articles Next Articles

Effect of Taurochenodeoxycholic Acid on Immunologic Function of Immunosuppressed Mice

HE Xiu-ling, LI Pei-feng, GUAN Hong, JIN Shao-lin

(College of Animal Science and Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China)

Received:1900-01-01 Revised:1900-01-01 Online:2010-05-20 Published:2010-05-20
Contact: LI Pei-feng

Abstract

Abstract: To study the effect of taurochenodeoxycholic acid (TCDCA) on cyclophosphamide-induced immunologic function of immunosuppressed mice. Immunosuppressed mice were established by peritoneal injection of cyclophosphamide (CTX, 50 mg/kg). TCDCA (100 mg/（kg·d）) was given by oral administration for 7 d. Using gravimetric method and spectrophotometry, the immune organ index, the antibody levels, the monocyte-macrophage phagocytosis and the lysozyme content of serum were determined. TCDCA had no significant impact on the thymus index, the spleen index and the hemolysin level of immunosuppressed mice serum; TCDCA could significantly improve the monocyte-macrophage phagocytic function and serum lysozyme levels of immunosuppressed mice. TCDCA could enhance immune function of CTX-induced immunosuppressed mice and had a certain protective effect to immune imbalance body.

Key words: taurochenodeoxycholic acid; cyclophosphamide; immune suppression

CLC Number:

S852.4

HE Xiu-ling;LI Pei-feng;GUAN Hong;JIN Shao-lin. Effect of Taurochenodeoxycholic Acid on Immunologic Function of Immunosuppressed Mice[J]. , 2010, 37(5): 57-59.

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Effect of Taurochenodeoxycholic Acid on Immunologic Function of Immunosuppressed Mice

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