China Animal Husbandry and Veterinary Medicine ›› 2022, Vol. 49 ›› Issue (12): 4635-4645.doi: 10.16431/j.cnki.1671-7236.2022.12.013

• Nutrition and Feed • Previous Articles     Next Articles

Effect of Taurine Additive Package on the Immune Function of Immunosuppressed Mice

GUO Zimeng1, WANG Fuzheng2, WANG Chengzhi2, DU Peng2, ZHANG Mingyue1, LI Zeyao1, SU Xiaochen1, WU Gaofeng1, YANG Jiancheng1   

  1. 1. College of Animal Science and Medicine, Shenyang Agricultural University, Shenyang 110866, China;
    2. Liaoning Haichen Pet Organic Food Co., Ltd., Chaoyang 122312, China
  • Received:2022-04-20 Online:2022-12-05 Published:2022-12-01

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Abstract: 【Objective】 This experiment was conducted to study the effect of adding taurine additive package in basic diet on the immune function of immunosuppressed mice.【Method】 80 mice were randomly and equally divided into four groups, mice in C and M groups were given basic diet, mice in H and MH groups were given diet containing 8.8% taurine additive package.The experiment was lasted for 51 days, the immunosuppressed mice model was established by intraperitoneal injection of 70 μg/g BW cyclophosphamide (CTX) for four consecutive days from the 31st day (in M and MH groups), while the other mice were intraperitoneally injected with the equal volume of normal saline.The feed intake and body weight were recorded to calculate the average daily gain (ADG) and average daily feed intake (ADFI).Effects of this immunopotentiator on immune organ index, cellular immunity, humoral immunity, non-specific immune function, levels of cytokines and immunoglobulins of mice were detected.【Result】 Compared with C group, mice in M group showed significant reduction in ADFI, ear swelling, serum hemolysin level, and immunoglobulin G(IgG) (P<0.05), while ADG, thymus index, splenic lymphocyte proliferation capacity, antibody-producing cell amount, abdominal macrophage phagocytosis, interleukin-6(IL-6) and immunoglobulin A(IgA) levels were extremely significantly reduced (P<0.01), and the spleen index was extremely significantly increased (P<0.01).There were no significant differences in carbon clearance index and immunoglobulin M(IgM) level between C and M groups (P>0.05).Compared with M group, mice in MH group had significantly increased ADFI, ADG, thymus index, spleen lymphocyte proliferation, ear swelling and IgM levels (P<0.05), extremely significantly increased serum hemolysin level, antibody-producing cell amount, abdominal macrophage phagocytosis, IL-6 and IgA levels (P<0.01), and significantly decreased spleen index (P<0.05).There was no significant difference in carbon clearance index and IgG levels between M and MH group (P>0.05).【Conclusion】 The taurine additive package administered in the present study could improve the innate and adaptive immunity, improve the levels of cytokines and immunoglobulins of mice with low immunity caused by CTX, and play a role in enhancing the immunity of mice.

Key words: taurine additive package; cyclophosphamide; mice; immunoregulation

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