牛磺鹅去氧胆酸对小鼠巨噬细胞系RAW264.7细胞凋亡的影响

doi:10.16431/j.cnki.1671-7236.2016.07.003

Abstract

Abstract:

We carried out the research of the effect of taurochenodeoxycholic acid (TCDCA) on the apoptosis of the mouse macrophage cell line RAW264.7 and expression of IAPs including CIAP-1,CIAP-2 and XIAP.The results showed that TCDCA with the dose of 0.05,0.10 and 10 μg/mL could extremely significantly prevent cells apoptosis that were induced by DEX (P < 0.01).TCDCA with the dose of 1 μg/mL could significantly promote mRNA expressions of CIAP-1 and XIAP (P < 0.05),while the dose of 10 μg/mL could significantly promote mRNA expressions of CIAP-1,CIAP-2 and XIAP (P < 0.05),TCDCA could also extremely significantly up-regulate the expression of CIAP-1,CIAP-2 and XIAP (P < 0.01) in RAW264.7 cell line by DEX,but this depended on different doses of TCDCA.The above research results showed that TCDCA could resist the cells apoptosis of the mouse macrophage cell line RAW264.7 that were induced by DEX,which was related with the influence on the mRNA expression of IAPs.

Key words: taurochenodeoxycholic acid; mouse macrophage cell line RAW264.7; cell apoptosis; IAPs

CLC Number:

Q255

ZHANG Wen, WANG Jian-guang, LI Jin-lian, ZHAO Xiao-min, CHEN Zheng-tao, ZHOU Chuan, SHI You-fei. Effect of Taurochenodeoxycholic Acid on the Proliferation of the Mouse Macrophage Cell Line RAW264.7[J]. , 2016, 43(7): 1674-1680.

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Effect of Taurochenodeoxycholic Acid on the Proliferation of the Mouse Macrophage Cell Line RAW264.7

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