硫化氢的生成及其在细胞凋亡和炎性反应中的作用

doi:10.16431/j.cnki.1671-7236.2018.12.012

Abstract

Abstract:

H₂S is a colorless and odorous gas,it is not only a toxic and harmful substance in livestock houses,but also is the third gas signal molecule after NO and CO.H₂S can be produced through decompositing and reducting of sulfur-containing organic compounds and sulfates by Salmonella,Helicobacter pylori,etc.in the gastrointestinal tract,and also through catalyzing sulfur-containing amino acid such as L-cysteine by cystathionine-β-synthase (CBS),cystathionine-γ-lyase (CSE),cysteine transferase (CAT) and 3-mercapto-pyruvate thiotransferase (3-MST).H₂S has a variety of physiological and pathological effects.It can inhibit mitochondrial respiration and blocks apoptosis through blocking cytochrome C (at high content),while also down-regulates anti-apoptotic genes such as BCL-2 and NF-κB to promote apoptosis.It can inhibit apoptosis by regulating Caspase3 (at low content),and also can play a thiolation reaction with NF-κB p65 to promote the expression of downstream anti-apoptotic genes and play an anti-apoptotic effect.High concentration of H₂S could up-regulate the expression of NF-κB,P38 and ERKE1/2 genes to promote inflammatory responses,low concentrations of H₂S could exert anti-inflammatory effects through inhibiting NF-κB signaling pathway.Summarizing the formation of H₂S gas and its dual roles in apoptosis and inflammatory response,this paper provides a reference for the understanding of the physiopathological mechanism of H₂S in the process of disease development.

Key words: H₂S; generation; cell apoptosis; inflammatory reaction

CLC Number:

S852.21

ZHANG Chengyu, WANG Yueying, XU Chunmei, ZHU Heshui, ZHONG Kai, LI Heping. Generation of H₂S and Its Role in Apoptosis and Inflammatory Response[J]. , 2018, 45(12): 3402-3407.

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Generation of H₂S and Its Role in Apoptosis and Inflammatory Response

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Generation of H2S and Its Role in Apoptosis and Inflammatory Response

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Generation of H₂S and Its Role in Apoptosis and Inflammatory Response