γ-氨基丁酸对LPS介导的机体炎性反应影响的研究进展

doi:10.16431/j.cnki.1671-7236.2018.08.011

Abstract

Abstract:

γ-aminobutyric acid (GABA) is an important neurotransmitter in mammals,it is mainly distributed in the central nervous system,with a wide range of regulatory functions.GABA can participate in the regulation of body homeostasis through the hypothalamic-pituitary-adrenocortical (HPA) axis,and it has a certain mitigation effect on the inflammatory response caused by harmful stimuli outside.The body will causes the increase of blood lipopolysaccharide (LPS) content under the stimulation of external stress and activate the Toll-like receptor 4 (TLR4)/NF-κB signaling pathway,resulting in the increase of the expression of inflammatory factors such as tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) and interleukin-8 (IL-8),eventually leading to the body's inflammatory response.GABA can reduce the damage by regulating the expression of the corresponding inflammatory cytokines to the organism when the inflammatory reaction occurs in the body.This article provides a brief overview of the physiological effect of GABA,the types of GABA receptors,and the function of GABA in the inflammatory response to the body,analyzes the effect of GABA on inflammatory response in the body and its relationship with LPS-induced inflammatory response,which provide a theoretical basis for the clinical use of GABA in the treatment of inflammatory response.

Key words: γ-aminobutyric acid (GABA); regulation; inflammatory factors; inflammatory reaction

CLC Number:

S852.4

SUN Shiping, ZHANG Chengyu, LI Heping, XU Chunmei, CHEN Peige, ZHONG Kai, WANG Yueying. Research Progress on Effect of γ-aminobutyric Acid on LPS-mediated Inflammation to the Body[J]. , 2018, 45(8): 2128-2134.

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Research Progress on Effect of γ-aminobutyric Acid on LPS-mediated Inflammation to the Body

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