lncRNA在顶复门原虫感染中的作用机制

doi:10.16431/j.cnki.1671-7236.2022.11.030

Abstract

Abstract: Long non-coding RNA (lncRNA) is an RNA with nucleic acid length greater than 200 nt, which does not encode or has limited coding ability.In the early days, it has been considered as genetic dark matter, but with the progress of molecular biology technology, more and more lncRNAs have been discovered.Studies have shown that lncRNA, as a key regulator of gene expression, can affect gene expression in histone modification, transcriptional regulation and post transcriptional regulation, and participate in almost all cell biological processes.Apicomplexan parasite is an obligate intracellular parasite with complex invasion mechanism.The research on the interaction between Apicomplexan parasites and their host has become the basis for the development of new anti-insect drugs.In recent years, it has been found that lncRNA, as a new type of regulatory factor, is widely involved in the interaction between Apicomplexan parasites and host cells, including infection immunity, development and differentiation, signal transduction and other cellular biological processes, which can not only help the host resist the invasion of parasites, but also help the parasites proliferate and develop in the cell, showing an important regulatory role in the occurrence and development of diseases.By summarizing the biological classification of lncRNA and its main functions in cell physiological processes, and combining the relevant studies of lncRNA in Apicomplexan parasites, which is mainly represented by Toxoplasma gondii, Plasmodium and Cryptosporidium in recent years, the author system arranged the mechanism of lncRNA in host immune response, parasite development and differentiation, epigenetic regulation and other aspects, in order to study the pathogenesis of Apicomplexan parasites, and provide new ideas and references for the research and development of efficient prevention and control technology.

Key words: lncRNA; Apicomplexan parasites; infection; interaction; regulation

CLC Number:

S852.72

ZHANG Yiqing, LI Juan, QI Nanshan, LIAO Shenquan, LYU Minna, LIN Xuhui, CAI Haiming, HU Junjing, ZHANG Jianfei, LI Yugu, SUN Mingfei. Mechanism of lncRNA in Apicomplexan Parasites Infection[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4392-4400.

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Mechanism of lncRNA in Apicomplexan Parasites Infection

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