miRNAs对骨骼肌调控的研究进展

doi:10.16431/j.cnki.1671-7236.2018.06.008

Abstract

Abstract:

microRNAs (miRNAs) are a class of small non-coding RNAs of 22 nt, extensively exists in a variety of organisms.miRNAs can degrade target mRNA or inhibit their translation through binding with the 3' UTR region of target genes by incompletely base-pairing,which negatively regulate gene expression at the post-transcriptional level,and then been widely involved in the regulation of growth, development, diseases and other biological processes.Skeletal muscle accounts for about 40% of the body weight, which is essential for animals to maintain normal growth and development.miRNAs play important roles in the processes of skeletal muscle development,regeneration and disease through targeting the key factors of different stages.As an important regulatory factor of skeletal muscle diseases, miRNAs have become detection markers and targeted therapeutic drugs of muscle-related diseases.In recent years, with the deepening of miRNAs research, it has been found that the regulation of miRNAs on skeletal muscle become a hot topic in the field of life science.The authors reviewed the advances in regulation of skeletal muscle cells proliferation,differentiation,regeneration and diseases by miRNAs in order to provide a theoretical basis for the treatment of muscle diseases and the improvement of meat quality in the future.

Key words: miRNAs; skeletal muscle; proliferation; differentiation; regeneration; diseases

CLC Number:

Q522

LING Xiaoxiao, TANG Peng, LIANG Chunnian, WU Xiaoyun, CHU Min, YAN Ping. Research Progress on miRNAs in Skeletal Muscle Regulation[J]. , 2018, 45(6): 1486-1492.

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Research Progress on miRNAs in Skeletal Muscle Regulation

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