短链脂肪酸调控骨骼肌生理功能研究进展

doi:10.16431/j.cnki.1671-7236.2023.06.012

Abstract

Abstract: In recent years, more and more attention has been paid to the interaction between gut microbiota and the whole life process of the host.Gut microbiota plays an irreplaceable role in maintaining the health of the host mainly through the production of bioactive absorbable metabolites.Short chain fatty acids (SCFAs) are the main metabolites produced by gut microbiota fermentation of dietary fiber, mainly including acetate, propionate and butyrate.As a medium mediating the interaction between gut microbiota and various organs of the host, SCFAs are widely involved in the physiological activities of the host, including skeletal muscle.As one of the largest and most important organs of the body, skeletal muscle is very important for the health of the body to maintain its normal physiological function.At present, the studies on the regulation of host by SCFAs, mainly focus on other tissues and organs, while there are still few studies on the regulation of skeletal muscle.In view of the extensive physiological effects of SCFAs and the importance of skeletal muscle itself, the current research on the gut-muscle axis theory, the production pathway and transport of SCFAs, and the regulation of skeletal muscle (mass, endurance, fiber properties) as metabolites of intestinal flora were reviewed, and the current research status and future research directions were prospected.This study aims to deepen the understanding of the physiological process of SCFAs in regulating skeletal muscle, and provide new ideas for exploring biological targets of skeletal muscle-related diseases.

Key words: short-chain fatty acids (SCFAs); skeletal muscle; mass; endurance; fiber properties

CLC Number:

Q445

YANG Guitao, MA Jideng, LI Xuewei, GE Liangpeng, ZHANG Jinwei. Research Advance on Regulation of Skeletal Muscle Physiology Function by Short Chain Fatty Acids[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2286-2295.

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Research Advance on Regulation of Skeletal Muscle Physiology Function by Short Chain Fatty Acids

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