circRNA作用机制及其对动物肌肉发育的影响

doi:10.16431/j.cnki.1671-7236.2018.08.028

Abstract

Abstract:

circRNA is a non-coding RNA (ncRNA) that does not have a 5' end cap structure and 3' end poly (A) tail structure but can stably exist in eukaryotic cells.circRNA that formed by reverse splicing is the hottest ncRNA in the past few years.Much more researches have proved that circRNA plays an extremely important regulatory roles in the life activities of organisms.According to the different composition,circRNA can be divided into exon candidates,intron candidates and candidates of the intron-exons.In addition,the function of circRNA depended on its cellular site-specification.circRNA located in the nucleus always regulates the transcriptional activity of hosting genes mainly at gene transcriptional level with RNA polymerase Ⅱ;circRNA in the cytoplasm plays a major function in the role of competitive endogenous RNA,and mainly competitive inhibition of miRNA and their target 3'UTR to regulate the expression levels of miRNA and their targets;Recent studies have shown that circRNA can also be translated into proteins or peptides.At present,the related circRNA research on animal muscle growth and development is still at the initial stage,and the related research is mainly about circRNA as a competitive endogenous RNA to play an important regulatory role.This paper summarized the discovery,classification,production mechanism,mode of action of circRNA and its effect on myocyte proliferation and differentiation in recent years.Finally,we proposed a prospective study of circRNA on muscle growth and development,and we hope our research could offer some useful experience for other researches.

Key words: circRNA; generation mechanism; mode of action; muscle

CLC Number:

S813

XIE Yueqin, CHEN Ting, LUO Junyi, XI Qianyun, ZHANG Yongliang, SUN Jiajie. Mechanism of circRNA and Its Effect on Development of Animal Muscles[J]. , 2018, 45(8): 2270-2275.

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Mechanism of circRNA and Its Effect on Development of Animal Muscles

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