绒山羊毛囊发育中非编码RNA的研究进展

doi:10.16431/j.cnki.1671-7236.2022.05.022

Abstract

Abstract: Non-coding RNA (ncRNA) refers to RNA transcribed from the genome,which does not encode proteins,but can perform certain biological functions at the RNA level.There are many kinds of non-coding RNA,and different kinds lead to different functions.Hair follicle is a special appendage of cashmere goat skin,which is located in the dermis of the skin and occurs in the embryonic stage of cashmere goat.Due to the transmission of signal molecules between dermal cells and epithelial cells,its development changes periodically,going through growth stage,degenerative stage and resting stage.In recent years,there are many reports on the role of ncRNA in the development of cashmere goat hair follicle.This paper summarizes the biogenesis of microRNA (miRNA),long-chain non-coding RNA (lncRNA) and circular RNA (circRNA) and their mechanisms in the development of cashmere goat hair follicles.miRNA is a ncRNA molecule with a length of 18-25 nt in eukaryotes,it can inhibit post transcriptional gene expression by specifically binding to target mRNA.In the development of cashmere goat hair follicles,miRNA regulates the cycle and regeneration ability of hair follicles by inhibiting the genes related to hair follicle development and the key molecules of related signal pathways.lncRNA is a ncRNA with a length of more than 200 nt,after splicing,it has a polyA tail and promoter structure,which can promote the proliferation and differentiation of hair follicle cells,and regulates the cycle activity of hair follicle development and villus growth by regulating the targeted expression of genes and interacting with a variety of signal pathways.circRNA is different from the traditional linear RNA,which is a closed circular RNA and contains many miRNA binding sites.It plays the role of miRNA molecular sponge in cashmere goat hair follicle development and villus growth,that is,through the mediation of miRNA,it regulates the expression of target genes,promotes the differentiation of hair follicle stem cells into secondary hair follicles,and then relieves the inhibitory effect of miRNA related to hair follicle development and villus growth on its target genes,to improve the expression level of target genes.Through the research review of miRNA,lncRNA and circRNA,it is hoped to provide a reference for the construction of the molecular regulation network of hair follicle growth and the in-depth study on the regulation mechanism of the hair follicle development,and provide a theoretical basis for the better use of modern molecular biology technology to improve the quality of cashmere in the future.

Key words: miRNA; lncRNA; circRNA; cashmere goat; hair follicle development

CLC Number:

S811.5

WANG Dong, LIANG Jiayue, WANG Xiaobing, FENG Juan, ZHANG Ru, XIA Huiyan, XIAO Hongmei. Research Progress of Non-coding RNA in the Development of Hair Follicles of Cashmere Goats[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1817-1827.

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Research Progress of Non-coding RNA in the Development of Hair Follicles of Cashmere Goats

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