Abstract: Stem cells can sustain self-renewal and generate all cell types of the body in vitro, the special function of the stem cells makes it become the hot spot in the area of regenerating medicine, tissue engineer and traumatic repair. Understanding the regulation mechanism of differentiation in stem cells is the precondition and the theoretical basis of stem cell application. Here we summarize the research progress of stem cell differential regulation, in order to provide the reference of stem cells research.

Key words: stem cells; self-renewal; differentiation; regulation