脂多糖免疫应激研究进展

doi:10.16431/j.cnki.1671-7236.2025.02.043

Abstract

Abstract: In recent years,immune stress caused by lipopolysaccharide (LPS) has become a potential threat in animal husbandry production.As a common bacterial endotoxin,LPS exhibits multiple immune activities and plays a important role in immune regulation and cell signal transduction.LPS can quickly activate the immune system of animals and triggering the secretion of various inflammatory factors such as tumor necrosis factor (TNF) and interleukin-1β (IL-1β).Moderate LPS stimulation can improve the animal’s disease resistance and help it effectively fight infection and external stress.However,excessive or long-term exposure to LPS may lead to excesstive activation of the animal’s immune system,cause inflammatory diseases,and even affect its production performance and health status.At present,LPS has been widely used to establish animal models related to immune stress.A deep understanding of the impact of LPS on immune stress in different animals is crucial to animal husbandry production, and is also the key to the development of veterinary drugs in the veterinary field.The author reviews the structure and function of LPS,the commonality and difference in immune stress induced by LPS in different animals,and the measures to alleviate immune stress induced by LPS.It also summarizes the establishment methods of LPS immune stress models and their applications in diseases,and provides suggestions and prospects for future research on animal immune stress induced by LPS,aiming to provide a reference for the research of LPS and the practice of animal husbandry production.

Key words: lipopolysaccharide (LPS); immune stress; immune regulation; animal model

CLC Number:

S852.3

LU Rui, SHENG Hui, GUO Yanyan, ZHANG Yuxin, YAO Dawei, GUO Xiaofei, RUAN Weibin, ZHANG Xiaosheng. Research Progress on Immune Stress of LPS[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(2): 946-958.

References

[1] 王卉,高凤仙.畜牧业中应激的危害及其作用机理和防治措施[J].饲料工业,2013,34(12):53-56.WANG H,GAO F X.The hazards,mechanisms,and prevention measures of stress in animal husbandry[J].Feed Industry,2013,34(12):53-56.(in Chinese)
[2] 陆奇,韩修远,赵亮,等.LPS诱发绵羊精子活力降低及TLR4基因的介导作用[J].中国畜牧杂志,2022,58(5):147-152.LU Q,HAN X Y,ZHAO L,et al.LPS induces decreased sperm motility in sheep and mediates the role of TLR4 gene[J] Chinese Journal of Animal Science,2022,58(5):147-152.in Chinese)
[3] BENNETT J E,DOLIN R,BLASER M J.Mandell,Douglas,and Bennett’s Principles and Practice of Infectious Diseases[M].Philadephia:Elsevier Saunders,2014.
[4] RIETSCHEL E T,KIRIKAE T,SCHADE F U,et al.Bacterial endotoxin:Molecular relationships of structure to activity and function[J].The FASEB Journal,1994,8(2):217-225.
[5] YANG N J,CHIU I M.Bacterial signaling to the nervous system through toxins and metabolites[J]. Journal of Molecular Biology,2017,429(5):587-605.
[6] LUKIW W J,LI W,BOND T,et al.Facilitation of gastrointestinal (GI) tract microbiome-derived lipopolysaccharide (LPS) entry into human neurons by amyloid beta-42(Aβ42) peptide[J].Frontiers in Cellular Neuroscience,2019,13:545.
[7] BARTON S M,JANVE V A,MCCLURE R,et al.Lipopolysaccharide induced opening of theblood brain barrier on aging 5XFAD mouse model[J]. Journal of Alzheimer’s Disease,2019,67(2):503-513.
[8] DE CARVALHO J R G,DEL PUPPO D,DE OLIVEIRA LITTIERE T,et al.Functional infrared thermography imaging can be used to assess the effectiveness of Maxicam Gel^® in pre-emptively treating transient synovitis and lameness in horses[J]. Frontiers in Veterinary Science,2024,11:1399815.
[9] CUI C,WEI Y,WANG Y,et al.Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets[J].Journal of Animal Science and Biotechnology,2024,15(1):4.
[10] BARRIENTOS-BLANCO M A.The study of hyperketonemia in the dairy cow[D].Maryland：University of Maryland,College Park,2023.
[11] KOSYREVA A M,MIROSHNICHENKO E A,TSVETKOV I S,et al.Morphofunctional characteristics of lung macrophages in rats with acute respiratory distress syndrome[J].Bulletin of Experimental Biology and Medicine,2023,175(6):822-827.
[12] MAZZIO E,BARNES A,BADISA R,et al.Functional immune boosters;The herb or its dead microbiome? Antigenic TLR4 agonist mamps found in 65 medicinal roots and algae’s[J]. Journal of Functional Foods,2023,107:105687.
[13] NOBLE T H,SAMSING F,WADE N,et al.Stimulation of shrimp (Penaeus monodon) hemocytes by lipopolysaccharide-like molecules derived from Novacq^TM[J].Animal Feed Science and Technology,2023,299:115626.
[14] TALAVERA M M,NUTHAKKI S,CUI H,et al.Immunostimulated arginase Ⅱ expression in intestinal epithelial cells reduces nitric oxide production and apoptosis[J]. Frontiers in Cell and Developmental Biology,2017,5:15.
[15] NASCIMENTO A F,ALVES G J,MASSOCO C O,et al.Lipopolysaccharide-induced sickness behavior in lactating rats decreases ultrasonic vocalizations and exacerbates immune system activity in male offspring[J].Neuroimmunomodulation, 2015,22(4):213-221.
[16] KURPIOS-PIEC D,WO AZ＇G NIAK K,KOWALEWSKI C,et al.Thiram modulates pro-inflammatory mediators in RAW264.7 murine macrophage cells[J]. Immunopharmacology and Immunotoxicology,2015,37(1):90-102.
[17] DONG J,LIAO Y,ZHOU W,et al.Porphyromonas gingivalis LPS-stimulated BMSC-derived exosome promotes osteoclastogenesis via miR-151-3p/PAFAH1B1[J].Oral Diseases,2024.Doi:10.1111/odi.15031.
[18] PARK K H,JANG Y S,JOO J Y,et al.Anti-inflammatory activity of no-ozone cold plasma in Porphyromonas gingivalis lipopolysaccharide-induced periodontitis rats[J].International Journal of Molecular Sciences,2024,25(11):6161.
[19] FENG N,HAN X,PENG D,et al.P.gingivalis alters lung microbiota and aggravates disease severity of COPD rats by up-regulating Hsp90α/MLKL[J]. Journal of Oral Microbiology, 2024,16(1):2334588.
[20] PRYWER J,TORZEWSKA A.Aggregation of poorly crystalline and amorphous components of infectious urinary stones is mediated by bacterial lipopolysaccharide[J]. Scientific Reports,2019,9(1):17061.
[21] DURLIK-POPI AN＇G SKA K, AZG ARNOWIEC P,LECHOWICZ Ł,et al.Antibodies isolated from rheumatoid arthritis patients against lysine-containing Proteus mirabilis O3(S1959) lipopolysaccharide may react with collagen type Ⅰ[J]. International Journal of Molecular Sciences,2020,21(24):9635.
[22] 杨文腰,王瀛,王琦,等.碱性羟胺,弱碱和乙酸水解奇异变形杆菌LPS抗原及其活性的影响[J].微生物学杂志,2016,36(6):88-92.YANG W Y，WANG Y,WANG Q,et al.The effects of alkaline hydroxylamine,weak base,and acetic acid hydrolysis on the LPS antigen and its activity of Proteus mirabilis[J].Journal of Microbiology,2016,36(6):88-92.(in Chinese)
[23] FERDOUS F,MAURICE D,SCOTT T.Broiler chick thrombocyte response to lipopolysaccharide[J]. Poultry Science,2008,87(1):61-63.
[24] RAVINDRAN R,LOEBBERMANN J,NAKAYA H I,et al.The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation[J].Nature,2016,531(7595):523-527.
[25] FENG Z,LI Q,MENG R,et al.METTL 3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells[J].Journal of Cellular and Molecular Medicine,2018,22(5):2558-2568.
[26] CHUANG H G,ABD AZIZ N N H,WONG J H,et al.Role of Toll-like receptor 4 antagonist lipopolysaccharide-Rhodobacter sphaeroides on acute stress-induced voluntary ethanol preference and drinking behaviour:In vivo swiss albino mouse model[J]. European Neuropsychopharmacology,2021,45:59-72.
[27] MUSCAT S M,DEEMS N P,BUTLER M J,et al.Selective TLR4 antagonism prevents and reverses morphine-induced persistent postoperative cognitive dysfunction,dysregulation of synaptic elements,and impaired BDNF signaling in aged male rats[J].Journal of Neuroscience,2023,43(1):155-172.
[28] KAWAKITA F,FUJIMOTO M,LIU L,et al.Effects of Toll-like receptor 4 antagonists against cerebral vasospasm after experimental subarachnoid hemorrhage in mice[J]. Molecular Neurobiology,2017,54:6624-6633.
[29] TSAI C F,CHEN G W,CHEN Y C,et al.Regulatory effects of quercetin on M1/M2 macrophage polarization and oxidative/antioxidative balance[J].Nutrients,2021,14(1):67.
[30] WANG Y,JASPER H,TOAN S,et al.Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury[J].Redox Biology,2021,45:102049.
[31] AHMED S,KWATRA M,PANDA S R,et al.Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease[J].Brain,Behavior,and Immunity,2021,91:142-158.
[32] KANG J Y,XU M M,SUN Y,et al.Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis[J].International Immunopharmacology,2022,109:108782.
[33] HE Y,LI Z,XU T,et al.Polystyrene nanoplastics deteriorate LPS-modulatedduodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway[J].Chemosphere,2022,307:135662.
[34] LIU Z,YAO X,SUN B,et al.Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury[J].Free Radical Biology and Medicine,2021,168:142-154.
[35] FERNÁNDEZ-MENDÍVIL C,LUENGO E,TRIGO-ALONSO P,et al.Protective role of microglial HO-1 blockade in aging:Implication of iron metabolism[J].Redox Biology,2021,38:101789.
[36] SHEN K,JIA Y,WANG X,et al.Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2/HO-1 axis in macrophages[J].Free Radical Biology and Medicine,2021,165:54-66.
[37] WARNER A E,DECAMP JR M M,MOLINA R M,et al.Pulmonary removal of circulating endotoxin results in acute lung injury in sheep[J]. Laboratory Investigation,1988,59(2):219-230.
[38] NAYLOR D,SHARMA A,LI Z,et al.Endotoxin-induced cytokine,chemokine and white blood cell profiles of variable stress-responding sheep[J].Stress,2021,24(6):888-897.
[39] SHANDILYA U K,SHARMA A,NAYLOR D,et al.Expression profile of miRNA from high,middle,and low stress-responding sheep during bacterial endotoxin challenge[J].Animals,2023,13(3):508.
[40] DENG S L,ZHANG B L,REITER R J,et al.Melatonin ameliorates inflammation and oxidative stress by suppressing the p38 MAPK signaling pathway in LPS-induced sheep orchitis[J].Antioxidants,2020,9(12):1277.
[41] KUNZMANN S，HVTTEN M,OTTENSMEIER B，et al.A20 is increased in fetal lung in a sheep LPS model of chorioamnionitis[J].Oxidative Medicine and Cellular Longevity,2022,2022:6421419.
[42] DOBSON H,TILSTON V,RESSEL L.Immunolocalization of c-Fos,ELOVL5 and oestradiol in the ewe vulva in relation to oestrus behaviour after treatment with lipopolysaccharide[J].Reproduction in Domestic Animals,2020,55(2):137-145.
[43] SAVIGNI D L,CHANG A Y,SORENSEN N L,et al.Airway smooth muscle thickness and contraction are enhanced by intra-amniotic lipopolysaccharide in an ovine model of premature birth[J].Journal of Applied Physiology,2022,133(4):959-969.
[44] ZARATE M A,WESOLOWSKI S R,NGUYEN L M,et al.In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep[J].Innate Immunity,2020,26(7):549-564.
[45] WANG S,ZHANG K,SONG X,et al.TLR4 overexpression aggravates bacterial lipopolysaccharide-induced apoptosis via excessive autophagy and NF-κB/MAPK signaling in transgenic mammal models[J].Cells,2023,12(13):1769.
[46] WANG S,SONG X,ZHANG K,et al.Overexpression of Toll-like receptor 4 affects autophagy,oxidative stress,and inflammatory responses in monocytes of transgenic sheep[J].Frontiers in Cell and Developmental Biology,2020,8:248.
[47] 同海妮,杨彦平,毕冠华,等.猪温病热盛证动物模型的建立[J].中兽医医药杂志,2022,41(6):76-80.TONG H N,YANG Y P,BI G H,et al.Establishment of an animal model of excessive heat syndrome in pigs[J].Journal of Traditional Chinese Veterinary Medicine,2022,41(6):76-80.(in Chinese)
[48] JIA A F,FENG J H,ZHANG M H,et al.Effects of immunological challenge induced by lipopolysaccharide on skeletal muscle fiber type conversion of piglets[J].Journal of Animal Science,2015,93(11):5194-5203.
[49] TANG X,XIONG K,FANG R,et al.Weaning stress and intestinal health of piglets:A review[J]. Frontiers in Immunology,2022,13:1042778.
[50] ZHOU Y,HU X,ZHONG S,et al.Effects of continuous LPS induction on oxidative stress and liver injury in weaned piglets[J].Veterinary Sciences,2022,10(1):22.
[51] TANG X,LIU B,WANG X,et al.Epidermal growth factor,through alleviating oxidative stress,protect IPEC-J2 cells from lipopolysaccharides-induced apoptosis[J].International Journal of Molecular Sciences,2018,19(3):848.
[52] 张歆明,徐舸,郑钦生,等.细菌脂多糖对猪圆环病毒2型在PK-15细胞中复制的影响[J].动物医学进展,2023,44(2):24-29.ZHANG X M,XU G,ZHENG Q S,et al.Effects of bacterial lipopolysaccharide on the replication of Porcine circovirus type 2 in PK-15 cells[J]. Progress in Veterinary Medicine,2023,44(2):24-29.(in Chinese)
[53] GOZHO G N，KRAUSE D O,PLAIZIER J C.Ruminal lipopolysaccharide concentration and inflammatory response during grain-induced subacute ruminal acidosis in dairy cows[J]. Journal of Dairy Science,2007,90:856-866.
[54] ZHANG K,CHANG G,XU T,et al.Lipopolysaccharide derived from the digestive tract activates inflammatory gene expression and inhibits case in synthesis in the mammary glands of lactating dairy cows[J].Oncotarget,2016,7(9):9652.
[55] SORDILLO L M.Mammary gland immunobiology and resistance to mastitis[J].Veterinary Clinics:Food Animal Practice,2018,34(3):507-523.
[56] KENT-DENNIS C,PENNER G B.Effects of lipopolysaccharide exposure on the inflammatory response,butyrate flux,and metabolic function of the ruminal epithelium using an ex vivo model[J].Journal of Dairy Science,2021,104(2):2334-2345.
[57] FORREST K K,FLORES V V,GURULE S C,et al.Effects of lipopolysaccharide on follicular estrogen production and developmental competence in bovine oocytes[J]. Animal Reproduction Science,2022,237:106927.
[58] SORDILLO L M,AITKEN S L.Impact of oxidative stress on the health and immune function of dairy cattle[J].Veterinary Immunology and Immunopathology,2009,128(1-3):104-109.
[59] 张兴,高英魁,郝中华,等.脂多糖对牛乳腺上皮细胞自噬和凋亡的影响[J].动物医学进展,2023,44(9):69-75.ZHANG X,GAO Y K,HAO Z H,et al.Effects of lipopolysaccharide on autophagy and apoptosis in bovine mammary epithelial cells[J]. Progress in Veterinary Medicine,2023,44(9):69-75.(in Chinese)
[60] YI D,HOU Y,WANG L,et al.Dietary N-acetylcysteine supplementation alleviates liver injury in lipopolysaccharide-challenged piglets[J].British Journal of Nutrition,2014,111(1):46-54.
[61] JI Z,WANG Z,CHEN Z,et al.Melatonin attenuates chronic cough mediated by oxidative stress via transient receptor potential melastatin-2 in guinea pigs exposed to particulate matter 2.5[J].Physiological Research,2018,67(2):293-305.
[62] PACKER L,WEBER S U,RIMBACH G.Molecular aspects of α-tocotrienol antioxidant action and cell signalling[J].The Journal of Nutrition,2001,131(2):369S-373S.
[63] FAGAN M M,HARRIS P,ADAMS A,et al.Form of vitamin E supplementation affects oxidative and inflammatory response in exercising horses[J]. Journal of Equine Veterinary Science,2020,91:103103.
[64] SASEGHI A，FAROOKHI F，SHALIZAR-JALALI A，et al.Protective effect of vitamin E on sperm quality and fertilizing potential and testosterone concentration in polyvinyl chloride treated male rats[J].Veterinary Research Forum：An International Quarterly Journal,2020,11(3):257-263.
[65] TRABER M G,STEVENS J F.Vitamins C and E:Beneficial effects from a mechanistic perspective[J].Free Radical Biology and Medicine,2011,51(5):1000-1013.
[66] WONG S K,CHIN K Y,IMA-NIRWANA S.Vitamin C:A review on its role in the management of metabolic syndrome[J].International Journal of Medical Sciences,2020,17(11):1625.
[67] NUNES V S,ANDRADE A R,GUEDES A L V,et al.Distinct phenotype of non-alcoholic fatty liver disease in patients with low levels of free copper and of ceruloplasmin[J].Arquivos de Gastroenterologia,2020,57:249-253.
[67] KLEVAY L M.Adding cholesterol to diets of animals induces copper deficiency and promotes oxidative damage[J].American Journal of Veterinary Research,2018,79(6):591.
[69] DE GRANDE A,LELEU S,DELEZIE E,et al.Dietary zinc source impacts intestinal morphology and oxidative stress in young broilers[J].Poultry Science,2020,99(1):441-453.
[70] LI S,ZHAO Q,ZHANG K,et al.Se deficiency induces renal pathological changes by regulating seleno protein expression,disrupting redox balance,and activating inflammation[J]. Metallomics,2020,12(10):1576-1584.
[71] ANAND P,KUNNUMAKKARA A B,NEWMAN R A,et al.Bioavailability of curcumin:Problems and promises[J].Molecular Pharmaceutics,2007,4(6):807-818.
[72] ESATBEYOGLU T,HUEBBE P,ERNST I M A,et al.Curcumin—From molecule biological function[J].Angewandte Chemie International Edition,2012,51(22):5308-5332.
[73] SPANIER G,XU H,XIA N,et al.Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1(SOD1),glutathione peroxidase 1(GPx1) and NADPH oxidase subunit (Nox4)[J].Journal of Physiology and Harmacology，2009,60(Suppl 4):111-116.
[74] ZHANG T,CHI Y,REN Y,et al.Resveratrol reduces oxidative stress and apoptosis in podocytes via Sir2-related enzymes,sirtuins1(SIRT1)/peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) axis[J].Medicalscience Monitor:International Medical Journal of Experimental and Clinical Research,2019,25:1220.
[75] RADWAN R R,KARAM H M.Resveratrol attenuates intestinal injury in irradiated rats via PI3K/Akt/mTOR signaling pathway[J]. Environmental Toxicology,2020,35(2):223-230.
[76] 宋国斌,席国萍,李艳花,等.快速制备鼻腔给予LPS诱导帕金森病动物模型及评价[J].中国免疫学杂志,2020,36(11):1353-1357.SONG G B,XI G P,LI Y H,et al.Rapid preparation of intranasal lipopolysaccharide-induced Parkinson’s disease animal model and evaluation[J]. Chinese Journal of Immunology,2020,36(11):1353-1357.(in Chinese)
[77] 孙静,赵荣华,孙建辉,等.雾化吸入给药BD-77对呼吸道合胞病毒感染及LPS致小鼠肺炎的治疗作用[J].病毒学报,2024,40(1):45-50.SUN J,ZHAO R H,SUN J H,et al.Therapeutic effect of nebulized inhalation of BD-77 on Respiratory syncytial virus infection and LPS-induced pneumonia in mice[J].Chinese Journal of Virology,2024,40(1):45-50.(in Chinese)
[78] LI Y,WEI H.Lipopolysaccharide “two-hit” induced refractory hypoxemia acute respiratory distress model in rats[J]. Journal of Huazhong University of Science and Technology (Medical Sciences),2009,29(4):470-475.
[79] SZARKA R J,WANG N,GORDON L,et al.A murine model of pulmonary damage induced by lipopolysaccharide via intranasal instillation[J]. Journal of Immunological Methods,1997,202(1):49-57.
[80] BÁNFI A,TISZLAVICZ L,SZÉKELY E,et al.Development of bronchus-associated lymphoid tissue hyperplasia following lipopolysaccharide-induced lung inflammation in rats[J].Experimental Lung Research,2009,35(3):186-197.
[81] ZHANG X P,ZHANG J,MA M L,et al.Pathological changes at early stage of multipleorgan injury in a rat model of severe acute pancreatitis[J]. Hepatobiliary & Pancreatic Diseases International,2010,9(1):83-87.
[82] SIMONS R K,JUNGER W G,LOOMIS W H,et al.Acute lung injury in endotoxemic rats is associated with sustained circulating IL-6 levels and intrapulmonary cinc activity and neutrophil recruitment—Role of circulating TNF-alpha and IL-beta?[J].Shock,1996,6(1):39-45.
[83] ELDER A C P,FINKELSTEIN J,JOHNSTON C,et al.Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice[J]. Inhalation Toxicology,2000,12(3):225-243.
[84] CHAE B S,PARK J S,SHIN T Y.Endotoxin induces late increase in the production of pulmonary proinflammatory cytokines in murine lupus-like pristane-primed model[J].Archives of Pharmacal Research,2006,29:302-309.
[85] ZHAO J,BI W,XIAO S,et al.Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice[J].Scientific Reports,2019,9(1):5790.
[86] ESCRIBANO B M,MEDINA-FERNÁNDEZ F J,AGUILAR-LUQUE M,et al.Lipopolysaccharide binding protein and oxidative stress in a multiple sclerosis model[J].Neurotherapeutics,2017,14:199-211.
[87] HIRAYAMA M,HASEGAWA S,MINATO T,et al.Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in PD[J].Parkinsonism & Related Disorders,2016,22:e32.
[88] ZHANG Y,XIE B,CHEN X,et al.A key role of gut microbiota-vagus nerve/spleen axis in sleep deprivation-mediated aggravation of systemic inflammation after LPS administration[J]. Life Sciences,2021,265:118736.
[89] HICKMAN S E,ALLISON E K,EL KHOURY J.Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer’s disease mice[J]. Journal of Neuroscience,2008,28(33):8354-8360.
[90] ZHOU J,YU W,ZHANG M,et al.Imbalance of microglial TLR4/TREM2 in LPS-treated APP/PS1 transgenic mice:A potential link between Alzheimer’s disease and systemic inflammation[J].Neurochemical Research,2019,44:1138-1151.
[91] TANG L,LIU L,LI G,et al.Expression profiles of long noncoding RNAs in intranasal LPS-mediated Alzheimer’s disease model in mice[J]. BioMed Research International,2019,2019:1-14.
[92] AGOSTINI A,YUCHUN D,LI B,et al.Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1 dE9 mouse model of Alzheimer’s disease[J].Brain, Behavior,and Immunity,2020,83:87-111.
[93] SHENG J G,BORA S H,XU G,et al.Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice[J].Neurobiology of Disease,2003,14(1):133-145.
[94] CLEMENTE-POSTIGO M,QUEIPO-ORTUÑO M I,MURRI M,et al.Endotoxin increase after fatoverload is related to postprandial hypertriglyceridemia in morbidly obese patients[J].Journal of Lipid Research,2012,53(5):973-978.
[95] ERRIDGE C,ATTINA T,SPICKETT C M,et al.A high-fat meal induces low-grade endotoxemia:Evidence of a novel mechanism of postprandial inflammation[J].The American Journal of Clinical Nutrition,2007,86(5):1286-1292.
[96] HARTE A L,VARMA M C,TRIPATHI G,et al.High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects[J].Diabetes Care,2012,35(2):375-382.
[97] CANI P D,AMAR J,IGLESIAS M A,et al.Metabolic endotoxemia initiates obesity and insulin resistance[J].Diabetes,2007,56(7):1761-1772.
[98] CREELY S J,MCTERNAN P G,KUSMINSKI C M,et al.Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes[J].American Journal of Physiology-Endocrinology and Metabolism,2007,292(3):E740-E747.
[99] HERSOUG L G,MØLLER P,LOFT S.Role of microbiota-derived lipopolysaccharide in adipose tissue inflammation,adipocyte size and pyroptosis during obesity[J].Nutrition Research Reviews,2018,31(2):153-163.
[100]CLEMENTE-POSTIGO M,OLIVA-OLIVERA W,COIN-ARAGVEZ L,et al.Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity[J].American Journal of Physiology-Endocrinology and Metabolism,2019,316(2):E319-E332.

Research Progress on Immune Stress of LPS

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	HE Jiayu, YANG Mingqi, WU Jiao, YANG Yu, YAO Huan, YI Jine, KONG Li. Establishment and Index Evaluation of Inflammatory Bowel Disease Model in C57BL/6 Mice [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(9): 4153-4163.
[2]	FENG Xiaomeng, GAO Chao, TAO Xinlei, LI Xiaofang, LYU Xiaoping, GAO Xueli, ZHAO Yi, LI Yanan, LIU Chaonan. Study on the Regulatory Role of the HIF-1α Signaling Pathway on Lipopolysaccharide-induced Inflammation in Chicken Macrophages [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(5): 2071-2080.
[3]	BAO Hua, HU Chunli, AN Yanhao, ZHANG Chunhua, MA Yanfen. Effects of EGCG on Inflammatory Injury and Apoptosis of BMECs Induced by LPS [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(5): 2122-2131.
[4]	JI Xinpeng, JIN Shiyu, TENG Hailong, ZHOU Yuze, LI Xiangzi, GAO Xu, LI Qiang. Research Progress on the Application of Mesenchymal Stem Cells in Animal Husbandry [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(3): 955-966.
[5]	LI Yuanyuan, MAO Yan, LIANG Zengenni, YANG Chenglin, WU Jing, YUAN Zhihang, YUAN Liyun. Research Progress on the Pharmacological Effects of Viola yedoensis Makino [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(7): 2998-3006.
[6]	ZHONG Yueyun, YANG Shuzhan, CHEN Feiyue, LU Zhier, LI Bingxin, LI Wanyan, TIAN Yunbo, HUANG Yunmao, XU Danning, CAO Nan. Effects of LPS on Apoptosis of Goose Embryo-derived Hepatocytes ROS/p38/MAPK Signaling Pathway [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2224-2232.
[7]	SHAO Yongbin, ZHENG Yichuang, ZHANG Jingyi, WEI Linying, TIAN Yong, SUN Guojie, LIU Yuran, LUO Yan, GU Xinli. Study on the Anti-inflammatory Effect of Leonurine on LPS-induced Endometritis in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2149-2155.
[8]	CHEN Shaojun, LI Gang, NAI Zida, LIU Di, JIANG Xinpeng. Research and Application of Gene-edited Probiotics in Animal Intestinal Health [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1016-1024.
[9]	GAO Jiahao, QIAO Yanjie, LIAN Kexun, WANG Mengmeng, GU Xinli, SHAO Yongbin. Effects of Glycyrrhizic Acid on Immune Performance of Lipopolysaccharide-stressed Yellow Feather Broilers [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3419-3427.
[10]	LIU Rui, LI Jiangling, DU Huarui, YANG Chaowu, CHEN Jialei, ZHAO Sujun, WANG Qiushi. Identification of Immune-Related circRNA of Thymus in Chickens [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2022-2032.
[11]	TANG Lin, ZHANG Junfang, WANG Ying, SUN Bin, WANG Enze, SHIN Jongsuh, GUO Panpan, JIN Xin, YAN Changguo, LI Xiangzi, LI Qiang. Anti-apoptotic Effect of Canine Adipose-derived Mesenchymal Stem Cells on Endoplasmic Reticulum Stress Model of Severe Acute Pancreatitis in vitro [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1840-1851.
[12]	ZHANG Yuzhu, YU Chao, ZHENG Huihua, TANG Xinyue, HUANG Ronglei, XIE Guanghong. Mechanism Study of Protocatechuic Acid on LPS-induced Endometritis in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1585-1591.
[13]	MA Sijia, LIU Yuan, WANG Xuzhong, LI Tingting, DUAN Xing, YANG Songbai, SONG Dan, LI Xiangchen. Effects of Melatonin on the Expression of Inflammatory Factors in Skeletal Muscle Satellite Cells Stimulated by LPS in Tan Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(9): 3378-3386.
[14]	GONG Lei, LANG Xi, MA Sha, CHEN Cui, ZHOU Zhenghong. Effects of Single High Dose and Multiple Low Dose Cyclophosphamide Abdominal Injection on Immunosuppressive Model in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(10): 3787-3794.
[15]	WANG Min, PENG Peiyuan, YANG Tai, DENG Pan, TIAN Kexiong. A Regulation Mechanism of Mannan Oligosaccharide on Intestinal Health and Immunity and Its Application in Livestock and Poultry Production [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(2): 433-441.