Abstract: Stem cells are a kind of pluripotent cells with strong proliferation and regeneration potential,which can regulate various functions in the body with low immunogenicity,and have great application potential in the field of animal husbandry.Mesenchymal stem cells (MSCs) are a kind of pluripotent cells,possessing all the commonalities of stem cells,with a wide range of sources,easy separation,low moral and legal constraints,and gradually advancing from basic research to clinical application stage.Through migration and paracrine mechanisms,MSCs play a regulatory role in vivo,such as resisting pathogen invasion,stabilizing immune response,reducing cell stress,and promoting tissue regeneration.However,the biological characteristics of MSCs from different tissue sources are different,and their surface markers are an important basis for identification.At present,the related research of MSCs has gradually expanded from the field of human and pet to animal husbandry,and has also shown strong application potential in large animals such as cattle and horses.With its anti-inflammatory repair ability,it can effectively protect the animal body,promote the prognosis of diseases,and enhance the economic value of animals.But because the relevant research is not deep enough,many problems can not be solved,which makes the large-scale application is limited.In order to further enhance the application potential of MSCs and accelerate the transformation from laboratory to practical application,research in the fields of cell culture,gene editing and biomaterials is also constantly expanding.Therefore,the author systematically reviewed relevant literature,introduced the source,characteristics and mechanism of MSCs,and summarized the research progress and application potential of MSCs in animal husbandry,in order to provide new ideas for the application of MSCS in animal husbandry.

Key words: mesenchymal stem cells; immune regulation; tissue repair; infection; inflammation