Abstract: Skeletal muscle is the main product of livestock and poultry,an important source of meat and protein for human beings,and also an important economic character of aquaculture.Skeletal muscle satellite cells (SCs)，located between the sarcolemma and basement membrane,are the stem cells of skeletal muscle,the regulation on proliferation and differentiation plays an important role in the development,maintenance,regeneration and restoration of skeletal muscle after birth,and are closely related to muscle production and quality.Long non-coding RNA (lncRNA) is non-coding RNA molecule with a length of more than 200 nucleotides and low or no protein-coding potential,which exists widely in the nucleus,organelles,cytoplasm and membrane of eukaryotic cells.By acting as competitive endogenous RNA (ceRNA),lncRNA serves as a sponge for target microRNA (miRNA),is participating in various biological processes such as gene expression regulation,epigenetic regulation,cell cycle and differentiation regulation,and organ development.With the development of transcriptomics,proteomics and metabolomics,new lncRNA involves in the regulation of skeletal muscle development in cattle,sheep,pigs,monkeys,chickens and mice have been discovered and reported.lncRNA regulates the activation,proliferation,differentiation and lipid metabolism of SCs.The authors review the key lncRNA,upstream and downstream targets,signaling pathway and mechanism in the proliferation and differentiation of skeletal muscle SCs,and forward prospect for the molecular mechanism and technical research of lncRNA regulating skeletal muscle SCs,in order to provide theoretical references for the muscle development,meat production performance and improvement of meat quality in livestock and poultry.

Key words: skeletal muscle satellite cells; long non-coding RNA; myogenic differentiation; proliferation; regulatory factor