Abstract: Sirtuin 2(SIRT2) is a nicotinamide adenine dinucleotide (NAD⁺) -dependent deacetylase capable of regulating protein acetylation modification, and is a member of the silence-message regulator family (Sirtuins), which has a variety of biological functions.It plays a regulatory role in neurodegeneration, cell differentiation, glucose and lipid metabolism, tumorigenesis, autophagy and other processes.Cellular autophagy is a protective mechanism that maintains body homeostasis by removing abnormal proteins or organelles, and has the role of promoting cell renewal and maintaining cell quality.Celluar autophagy can be divided into three main forms, including macroautophagy, microautophagy and chaperon-mediated autophagy, all of which use lysosomes to degrade or recycle damaged organelles, misfolded and aggregated proteins, and other macromolecules, among which macroautophagy is the most studied, which is divided into macroautophagy (commonly known as autophagy) and selective macroautophagy.Mitochondrial autophagy is a major pathway for selective removal or degradation of damaged and redundant mitochondria in eukaryotic cells, and is also a selective macroautophagy mainly regulated by SIRT2 in cells.The authors mainly review the regulatory role and mechanism of SIRT2 on autophagy and mitochondrial autophagy, in order to provide reference and direction for further research on more regulatory functions of SIRT2 in mammalian physiology and its therapeutic effects on various diseases.

Key words: Sirtuin 2 (SIRT2); autophagy; mitophagy; regulation mechanism