脂肪相关lncRNAs在动物中的研究进展

doi:10.16431/j.cnki.1671-7236.2019.07.017

Abstract

Abstract:

Fat is an important energy storage material in animals,and is closely related to important economic traits such as lean percent.The development of fat is a complex and accurate process which is regulated by a variety of lipogenesis-related genes,transcriptional regulators and epigenetic factors.Long non-coding RNAs (lncRNAs) is a type of non-coding RNAs with a transcription length greater than 200 nt,which can regulate the expression of target genes through many pathways such as in transcription level,post-transcriptional level and epigenetic modification level,and then regulate life activities of animals.In recent years,the research on lncRNAs has gradually increased,its functional scope covers almost all aspects of life activities,and some lncRNAs have been shown to play important regulatory roles in the process of fat development.For example,brown fat lncRNA 1 (Blnc1) was shown to promote brown and beige adipocyte differentiation through a ribonucleoprotein complex that acts through early B-cell factor 2 (Ebf2) to enhance expression of thermogenic genes such as uncoupling protein 1 (Ucp1),and lnc-BATE1 is required for BAT adipogenesis and maintenance through binding with the heterogeneous nuclear ribonucleoprotein U (hnRNPU).In addition,lncRNA SRA can promote preadipocytes to adipocytes differentiation and further regulate the function of fat through binding to peroxisome proliferator-activated receptor gamma (PPARγ) and enhance PPARγ activity and many other pathways.The authors reviews the basic characteristics,action mechanism and research methods of lncRNAs,as well as the research results of lncRNAs related to fat development at home and abroad,in order to provide a reference for further exploring the regulation mechanism of lncRNAs on fat development.

Key words: lncRNAs; fat development; regulation mechanism

CLC Number:

LIU Yibing, AO Hong, XING Kai, WANG Chuduan. Research Progress on Fat-related lncRNAs in Animals[J]. , 2019, 46(7): 2021-2029.

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Research Progress on Fat-related lncRNAs in Animals

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