白消安致小鼠睾丸损伤的机理及其调控通路的研究进展

doi:10.16431/j.cnki.1671-7236.2023.07.021

Abstract

Abstract: Because of its strong toxic effect on spermatogonium, busulfan is often used to prepare spermatogonium stem cell transplantation recipients, but the specific toxic mechanism is still unclear, which affects its scientific use and effect improvement.Studies have shown that busulfan can cause oxidative stress and inflammatory response of spermatogenic cells, inhibit autophagy, damage blood-testis barrier, and poison spermatogenic function of testis, but the relationship between them and the regulatory pathway remain unclear.Based on the important regulatory role of nuclear transportation factor κB(NF-κB) pathway in inflammatory response, the author reviewed the research results of oxidative stress, inflammatory response, damage of blood-testis barrier and inhibition of testicular cell autophagy caused by busulfan, and analyzed the possible regulatory role of NF-κB signaling pathway in testicular toxicity of busulfan.The aim of this study was to reveal the toxic mechanism of busulfan to spermatogenesis, and to provide reference for scientific use of busulfan and to avoid environmental toxins.

Key words: busulfan; testis; oxidative stress; inflammatory reaction; blood-testis barrier; autophagy

CLC Number:

S814.1

WU Kaihui, ZHOU Chengli, ZHAO Lingjun, XU Shiyuan, LIU Songqi, DONG Zhihao, YUAN Kaimin, WANG Dong. Research Progress on the Mechanism and Regulatory Pathway of Testicular Injury Induced by Busulfan in Mice[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(7): 2811-2819.

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Research Progress on the Mechanism and Regulatory Pathway of Testicular Injury Induced by Busulfan in Mice

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