Abstract: Two kinds of inactivated oil-emulsion pseudorabies virus vaccine were used to inoculate rabbits which were not detected PRV antibody,every group had three rabbits,the control group was not inoculate vaccine.Their serum were collected at regular intervals.Latex agglutination test(LAT) and neutralization test(NT) were used to detect the antibody in serum .The results showed that LAT method can detect PRV antibody after 7 days ,and NT method can detect PRV antibody after 21 days.After 28 days inoculated,rabbits were infected with PRV.The experimental groups did not show significant clinical symptom, the control group rabbits were all died. The results showed that when the PRV LAT≥1∶45.3 or NT≥1∶8 ,the rabbit inoculated with the vaccine could resist PRV infection.

Key words: inactivie pseudorabie vaccine; rabbit; animal model