白藜芦醇对黄曲霉毒素B1致兔肾脏损伤的保护作用

doi:10.16431/j.cnki.1671-7236.2024.01.016

Abstract

Abstract: 【Objective】 This study explored the protective effect of resveratrol (Res) on kidney injury in rabbits induced by aflatoxin B₁ (AFB₁).【Method】 21 rabbits aged 40 days were randomly divided into 3 groups, 7 rabbits in each group, which were control group, AFB₁ group and AFB₁+Res group.The rabbits in control group was fed with basic diet, in AFB₁ group was fed with basal diet containing 0.3 mg/kg BW AFB₁, in AFB₁+Res group was fed with basal diet containing 0.3 mg/kg BW AFB₁ and 30 mg/kg BW Res.The experiment period was 21 days.At the end of the experiment, the pathological changes of kidney tissues in rabbit were observed, and the contents of creatinine (CRE), urea nitrogen (BUN) and uric acid (UA) in serum were detected.And the glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), total antioxidant capacity (T-AOC) and malonaldehyde (MDA) contents/activeties in kidney tissues were evaluated.【Result】 Compared with the control group, the pathological changes in the kidneys of rabbits in AFB₁ group included narrowed capsular space, disordered arrangement of renal tubular epithelial cells, fuzzy and exfoliated nuclei, and glycogen accumulation in the kidneys.The contents of CRE, BUN and UA in serum of rabbits in AFB₁ group were significantly increased (P<0.05).The activities of GSH-Px, SOD and T-AOC in the kidney tissues of rabbits in AFB₁ group were significantly decreased (P<0.05), and the level of MDA was significantly increased (P<0.05).Compared with AFB₁ group, for the rabbits in Res+AFB₁ group, the renal tissue structure damage in kidney was alleviated and the accumulation of glycogen was significantly reduced, the contents of CRE, BUN and UA in serum were significantly decreased, the levels of GSH-Px, SOD and T-AOC in the kidney tissue were significantly increased (P<0.05), and the level of MDA was significantly decreased (P<0.05).【Conclusion】 Adding Res in the diet could effectively alleviate the kidney damage caused by AFB₁ via improving the antioxidant capacity to regulate the level of oxidative stress of kidney in the rabbit.

Key words: rabbit; resveratrol; aflatoxin B₁; kidney injury

CLC Number:

S816.7

LIU Weiqi, ZHANG Yiyang, ZHANG Ziqiang, DING Ke, LIU Yumei. Protective Effect of Resveratrol on Kidney Injury Induced by Aflatoxin B₁ in Rabbits[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(1): 153-159.

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Protective Effect of Resveratrol on Kidney Injury Induced by Aflatoxin B₁ in Rabbits

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Protective Effect of Resveratrol on Kidney Injury Induced by Aflatoxin B1 in Rabbits

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Protective Effect of Resveratrol on Kidney Injury Induced by Aflatoxin B₁ in Rabbits