China Animal Husbandry and Veterinary Medicine ›› 2025, Vol. 52 ›› Issue (3): 1080-1088.doi: 10.16431/j.cnki.1671-7236.2025.03.010

• Nutrition and Feed • Previous Articles    

Effects of Dietary Chlorogenic Acid on Reproductive Performance of Female Rabbits and Growth of Suckling Rabbits

TAO Siming1,2, LIANG Hui1,2, YAN Chang1,2, LONG Runze1,2, XU Ruiqing1,2, LI Zixu1,2, WU Yingjie1,2, LIU Ning1,2, QIN Yinghe1,2   

  1. 1. State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China;
    2. National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
  • Received:2024-06-25 Published:2025-02-22

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Abstract: 【Objective】 This study was conducted to investigate the effects of chlorogenic acid (CGA) supplementation on reproductive performance of female rabbits and the growth of their offspring,as well as to screen optimal dosage of CGA.【Method】 Four hundred and sixty Hyla female rabbits with similar body weight and parity were randomly divided into five groups:Control group (basal diet),CGA200 group (basal diet＋200 mg/kg CGA),CGA400 group (basal diet＋400 mg/kg CGA),CGA600 group (basal diet＋600 mg/kg CGA),and CGA800 group (basal diet＋800 mg/kg CGA).The test diets were administered from 6 d before female rabbits mating until 35 d postpartum (weaning of suckling rabbits).Blood samples were collected from pregnant female rabbits on 15 d of pregnancy for the assessment of serum progesterone and estradiol levels,as well as the determination of total antioxidant capacity (T-AOC),activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px),and malondialdehyde (MDA) levels.The postpartum performance of each female rabbit was recorded,including conception rate,litter size,number of live-born kits,weight of live-born kits,total litter weight,and number of kits born dead.Furthermore,the conception rate and live birth rate were calculated based on this data.Additionally,the number of kits per litter and the litter weight were recorded in a fasted state at 7,14,21,and 35 d,and the average weight of kits was calculated based on these parameters.【Result】 Compared to the control group,①The treatment of CGA400 significantly increased the litter size,the number of kits born alive,the total litter weight,and the litter weight born alive (P＜0.05).The treatment of CGA800 significantly increased the total litter weight and the litter weight born alive (P＜0.05).②The litter weight and average weight of kits at 7 days were significantly increased in CGA400,CGA600,and CGA800 groups (P＜0.05),and the average weight of kits at 14 days was significantly increased in CGA600 group (P＜0.05).The litter weight at 21 days were significantly increased in CGA400,CGA600,and CGA800 groups (P＜0.05),and the litter weight of the weaning kits at 35 days were significantly improved in all groups supplemented with CGA (P＜0.05).③The average daily feed intake during pregnancy was significantly increased in CGA200,CGA400,and CGA600 groups (P＜0.05).④The serum estradiol level at 15 days of pregnancy was significantly elevated in group CGA400 (P＜0.05),and the serum level of total antioxidant capacity were significantly increased in CGA400 and CGA600 groups (P＜0.05).The activities of SOD and GSH-Px were significantly enhanced in all CGA groups (P<0.05),while malondialdehyde (MDA) level in serum was significantly reduced (P＜0.05).【Conclusion】 Dietary supplementation of appropriate amount of CGA could improve reproductive performance of female rabbit,promote growth of suckling rabbits,and reduce oxidative stress levels in female rabbits,and the best effect was achieved with a dosage of 400 mg/kg.

Key words: chlorogenic acid; female rabbits; reproductive performance; suckling rabbits; oxidative stress

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