全基因组关联分析的扩展方法及其在畜禽中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2024.04.006

Abstract

Abstract: Genome-wide association studies (GWAS) is a method of comparing genotype and phenotype data on a large sample set to identify genetic variations associated with specific traits.With the continuous development of high-throughput sequencing technology,bioinformatics technology,and statistical methods,some genetic variations or small molecular substances with lower frequencies can be detected more accurately and economically.The extension method of GWAS derived from technological progress provides new ideas for precision breeding and genetic improvement of livestock and poultry,including GWAS based on copy number variation (CNV),structural variation (SV),and tandem repeats (TR),and GWAS based on haplotypes,gene expression,and metabolomics.Researchers hope to use different molecular markers to provide more comprehensive and detailed genetic variation information to enhance the interpretability and accuracy of GWAS,or further explain and deepen the results of GWAS by combining other types of data,in order to deeply study the relationship between genetic variation and traits and identify key genes that affect complex traits.The author introduces the application of GWAS based on different molecular markers in livestock and poultry research and discusses its results.The advantages and feasibility of different methods are analyzed,providing more ideas and support for further promoting the application of GWAS in livestock and poultry research,precision breeding,and genetic improvement.

Key words: genome-wide association studies (GWAS); livestock and poultry; molecular markers

CLC Number:

S813.3

XIE Xinfeng, WANG Ziyi, ZHONG Ziqi, PAN Deyou, NI Shiheng, XIAO Qian. Advances in Extended Methods of Genome-Wide Association Studies and Their Applications in Livestock and Poultry[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(4): 1382-1389.

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Advances in Extended Methods of Genome-Wide Association Studies and Their Applications in Livestock and Poultry

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