家畜毛色形成分子基础及应用研究进展

doi:10.16431/j.cnki.1671-7236.2019.09.021

Abstract

Abstract: Animal coat color is an easily recognized phenotypes,and also be used as an effective measures of screening for some diseases.Coat color is mainly determined by the distribution,proportion and production rate of eumelanin and pheomelanin which were produced by melanocytes.Many genes play an important regulatory role in the production and distribution of melanin,and different genotypes of each gene form a variety of basic coat color,fade coat color and spot.In addition,miRNA binds the mRNA of coat color major gene to induce inhibition/enhancement of its transcription and translation process,thereby regulating the expression of coat color gene and affecting the synthesis of melanin.In this paper,the relationship between the coat color traits,diseases and DNA sequence polymorphisms (different genotypes) of major candidate genes MC1R,ASIP,KIT,TYRP,MITF,EDNRB in livestock were briefly described.The research progress on coat color formation miRNA mining and identification,miRNA regulation of major coat color genes,and the application value of coat color gene were analyzed which would provide a theoretical basis for future study on coat color mechanism of livestock.

Key words: livestock; coat color; main effect gene; miRNA; application value

CLC Number:

S828

WUDUBALA, WU Tiecheng, LI Yurong, LI Chun, WU Jianghong, HUSILE, LIU Bin, GAO Shuxin. Research Progress on Molecular Basis and Applicability of Coat Color Formation in Livestock[J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(9): 2665-2675.

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Research Progress on Molecular Basis and Applicability of Coat Color Formation in Livestock

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