miRNA在哺乳动物配子发生中的作用研究进展

doi:10.16431/j.cnki.1671-7236.2022.02.024

Abstract

Abstract: The gene expression regulation of gametogenesis in mammals includes stage-specific expression regulation of coding genes together with transcription and post-transcriptional regulation of non-coding genes.As a type of small non-coding RNA, miRNA can lead to mRNA degradation or protein translation inhibition by recognizing the binding site of the untranslated region of the target gene, thereby playing a regulatory role at the post-transcriptional level.In recent years, the role of miRNA in mammalian reproduction has been gradually revealed.More and more studies have shown that miRNA plays an important regulatory role in mammalian spermatogenesis, sperm maturation, oocyte maturation, follicular development, and early embryonic development.miRNA can indirectly or directly play a regulatory role in different stages of spermatogenesis by regulating the proliferation and apoptosis of Sertoli cells or the cell cycle progression of spermatogonia, spermatocytes and sperm cells.miRNA can also regulate the development and maturation of oocytes by regulating the proliferation, apoptosis, hormone synthesis and intercellular interaction of oocytes, cumulus cells and granulosa cells.This article mainly introduces the tissue- and stage-specific expression of miRNA during mammalian gametogenesis and their regulatory effects on target genes, in order to provide reference for further research on the regulatory mechanism of mammalian gametogenesis.

Key words: miRNA; spermatogenesis; sperm maturation; oogenesis

CLC Number:

Q527

HUANG Xiaogang, HAN Beibei, LI Ju, ZHANG Shouquan. Advance on the Role of microRNA in Mammalian Gametogenesis[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 624-630.

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Advance on the Role of microRNA in Mammalian Gametogenesis

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