硫酸头孢喹肟脂质体的毒理学试验及安全性评价

doi:10.16431/j.cnki.1671-7236.2017.08.043

Abstract

Abstract:

The purpose of this study was to evaluate the safety of the cefquinome sulfate liposomes by using the acute toxicity test, local irritation test and chronic toxicity test. The results showed that the LD₅₀ of cefquinome sulfate liposomes was 639.73 mg/kg after intramuscular injection of its suspension and 95% confidence interval was 573.06 to 714.17 mg/kg. There was no significant stimulation to muscle. Subchronic toxicity test showed that the weight, haematological indexes and biochemical criterion of rabbits in variety dose had no significant difference compared with normal group (P>0.05). There was no visible pathological changes on the liver,kidney histology. According to pathological observation, the structure of liver and kidney were clear in treated and middle dose groups,but there existed disorganized hepatic cell cord in the liver and hemorrhag between glomerulopathy,tubulointerstitial and hepatic sinusoids in high dose group. All results proved that the cefquinome sulfate liposomes was safe and reliable based on the animal experiments.

Key words: cefquinome sulfate; liposomes; acute toxicity; local irritation; safety evaluation

CLC Number:

S859.7

WU Hai-gang, XU Guang-ke, HU Jing, LIU Jin-ni, CHEN Qin-xi, ZHANG Ying-bing, JI Wan-min, YI Ben-chi, MA Yun. Toxicology Test and Safety Evaluation of Cefquinome Sulfate Liposomes[J]. , 2017, 44(8): 2523-2528.

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Toxicology Test and Safety Evaluation of Cefquinome Sulfate Liposomes

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