›› 2018, Vol. 45 ›› Issue (9): 2582-2590.doi: 10.16431/j.cnki.1671-7236.2018.09.031

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Study on Acute and Sub-chronic Toxicity Study of Zixiekang Oral Liquid

LUO Lirong1,2, WANG Hui2, CUI Dongan2, WANG Fuhe2, WANG Shengyi2   

  1. 1. College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830000, China;
    2. Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Animal Husbandry and Pharmaceutical Science, Lanzhou 730000, China
  • Received:2018-01-25 Online:2018-09-20 Published:2018-09-26


The aim of this experiment was to evaluate the safety of Zixiekang oral liquid by acute toxicity test in mice and sub-chronic toxicity test in rats,so as to provide theoretical basis for clinical use of drugs.Acute toxicity test was conducted in 36 mice by oral administration with the maximum dose method.In sub-chronic toxicity test,80 rats were randomly divided into high,medium,low dose and control groups,the respective dose of the experimental groups were 24,12 and 6 g/(kg·BW) by oral administration,and the control group was given saline at the same volume for 30 days.The weight of the rats was measured after withdrawal.The blood routine index,blood biochemical index,viscera index were calculated.The results showed that no mice died in acute toxicity test,LD50 could not be calculated,and there was no death in maximum tolerance test.In the sub-chronic toxicity test,weight gain of Wistar rats in the treatment group had no significant effect;There were no distinct abnormal changes in parenchymal organs other than the hepatocytes at the distal end of the vein showed swelling of varying degrees while no necrosis or inflammatory reaction in high dose treatment group,and there was no significant difference in hematological,biochemical and visceral indexes compared with control group (P>0.05).According to the acute toxicity of xenobiotics classification standard (WHO),the formulations were no toxic substances,high safety.Thus,the Zixiekang oral liquid was safe in clinical treatment.

Key words: Zixiekang oral liquid; acute toxicity test; sub-chronic toxicity test

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