仔泻康口服液的急性毒性和亚慢性毒性试验研究

doi:10.16431/j.cnki.1671-7236.2018.09.031

Abstract

Abstract:

The aim of this experiment was to evaluate the safety of Zixiekang oral liquid by acute toxicity test in mice and sub-chronic toxicity test in rats,so as to provide theoretical basis for clinical use of drugs.Acute toxicity test was conducted in 36 mice by oral administration with the maximum dose method.In sub-chronic toxicity test,80 rats were randomly divided into high,medium,low dose and control groups,the respective dose of the experimental groups were 24,12 and 6 g/(kg·BW) by oral administration,and the control group was given saline at the same volume for 30 days.The weight of the rats was measured after withdrawal.The blood routine index,blood biochemical index,viscera index were calculated.The results showed that no mice died in acute toxicity test,LD₅₀ could not be calculated,and there was no death in maximum tolerance test.In the sub-chronic toxicity test,weight gain of Wistar rats in the treatment group had no significant effect;There were no distinct abnormal changes in parenchymal organs other than the hepatocytes at the distal end of the vein showed swelling of varying degrees while no necrosis or inflammatory reaction in high dose treatment group,and there was no significant difference in hematological,biochemical and visceral indexes compared with control group (P>0.05).According to the acute toxicity of xenobiotics classification standard (WHO),the formulations were no toxic substances,high safety.Thus,the Zixiekang oral liquid was safe in clinical treatment.

Key words: Zixiekang oral liquid; acute toxicity test; sub-chronic toxicity test

CLC Number:

S853.76

LUO Lirong, WANG Hui, CUI Dongan, WANG Fuhe, WANG Shengyi. Study on Acute and Sub-chronic Toxicity Study of Zixiekang Oral Liquid[J]. , 2018, 45(9): 2582-2590.

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Study on Acute and Sub-chronic Toxicity Study of Zixiekang Oral Liquid

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