黄花补血草总黄酮亚急性毒性试验

doi:10.16431/j.cnki.1671-7236.2016.08.028

Abstract

Abstract:

To evaluate the safety of the total flavonoids of Limonium aureum (L.) Hill.and lay an experimental basis to study the pharmacological effects and clinical safety in the future,80 Wistarrats with same age and body weight were randomly divided into two groups (group Ⅰ,Ⅱ),and every group was divided into the high dose group (HG),medium dose group (MG),low dose group (LG) and control group (CG),respectively,of which the mice were given to the total flavonoids of Limonium aureum (L.) Hill.by gavage at the doses of 15,10 and 5 g/kg while the mice of CG were not given any medicine.The blood sample were collected and experimental indexes were measured at 10 (group Ⅰ) and 21 d (group Ⅱ).The results showed that comparing with CG,the weight gain of rats in MG and LG of group Ⅰhad no significant difference (P>0.05),and that of HG were significantly decreased (P<0.05);The weight gain of rats in LG of group Ⅱ had no significant difference (P>0.05),and that of MG and HG were significantly decreased (P<0.05);Organ indexes of experimental groups had no significant difference with CG (P>0.05);With increasing concentration of the total flavonoids of Limonium aureum (L.) Hill.,there was pathological damage to major organs and white lumps in lung and red bleeder existed in liver of rats in HG when given total flavonoids of Limonium aureum (L.) Hill.for 21 d.The results indicated that total flavonoids of Limonium aureum (L.) Hill.was low toxicity and could be safely used for animals with minding the dose was not too high.

Key words: total flavonoids of Limonium aureum(L.) Hill.; subacute toxicity test; rat; safety evaluation

CLC Number:

R285

LIU Yu, ZENG Hao-jie, SHANG Ruo-feng, HAO Bao-cheng, YANG Zhen, GUO Wen-zhu, CHENG Fu-sheng, WANG Xue-hong, LIANG Jian-ping. Subacute Toxicity Test of the Total Flavonoids of Limonium aureum (L.)Hill.[J]. , 2016, 43(8): 2135-2142.

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Subacute Toxicity Test of the Total Flavonoids of Limonium aureum (L.)Hill.

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