›› 2011, Vol. 38 ›› Issue (8): 43-47.

• 生物技术 • 上一篇    下一篇

microRNA与胎盘发育关系的研究进展

张玉玲1, 夏银可2, 靳丽军1, 翟小伟1, 付祥龙1, 陈晓丽1, 麻雪刚1, 刘凤军1   

  1. 1. 河南科技大学,河南洛阳 471003;2. 河南科技学院,河南新乡 453003
  • 收稿日期:2011-06-01 修回日期:1900-01-01 出版日期:2011-08-20 发布日期:2011-08-20
  • 通讯作者: 刘凤军

Advances in the Relationship between microRNA and Placental Development

ZHANG Yu-ling1, XIA Yin-ke2, JIN Li-jun1, ZHAI Xiao-wei1, FU Xiang-long1, CHEN Xiao-li1, MA Xue-gang1, LIU Feng-jun1   

  1. 1. Henan University of Science and Technology,Luoyang 471003, China;2. Henan Institute of Science and Technology,Xinxiang 453003, China
  • Received:2011-06-01 Revised:1900-01-01 Online:2011-08-20 Published:2011-08-20

摘要: microRNA (miRNA)是一类大小约22 nt的内源性非编码RNA,它们通过剪切靶基因的转录产物或抑制靶基因转录产物的翻译,在转录后起到调控靶基因表达的作用。大量研究结果表明,动物体内的miRNA参与了胚胎的早期发育、脑和神经发育、心脏发育、肌肉及骨骼发育等动物发育的各个方面。已有证据表明,一些miRNA在胎盘中特异表达,在胎盘的正常发育过程中起到了重要作用。作者对参与胎盘发育的miRNAs进行了综述。

关键词: miRNA; 胎盘; 调控因子; 发育

Abstract: miRNAs are a kind of endogenous, non-coding RNA of about 22 nucleotides in length, which can regulate the target gene expression at post-transcriptional level by trimming the transcript or repressing the translation. Plenty of studies showed that miRNAs in animals played important roles in animal developmental process, such as early embryonic development, brain and neurological development, cardiac development, bone and muscle development and so on. There are evidences demonstrating that some miRNAs are specifically expressed in placenta and play an important role in placental normal development. Therefore, we gave a key reference to miRNAs involved in placental development in this article.

Key words: miRNA; placenta; regulator; development

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