中国畜牧兽医 ›› 2022, Vol. 49 ›› Issue (1): 197-207.doi: 10.16431/j.cnki.1671-7236.2022.01.021
史源钧, 米思远, 俞英
收稿日期:
2021-09-06
出版日期:
2022-01-05
发布日期:
2021-12-29
通讯作者:
俞英
E-mail:yuying@cau.edu.cn
作者简介:
史源钧,E-mail:2019304010422@cau.edu.cn。
基金资助:
SHI Yuanjun, MI Siyuan, YU Ying
Received:
2021-09-06
Online:
2022-01-05
Published:
2021-12-29
摘要: N6-甲基腺嘌呤(N6-methyladenosine,m6A)修饰是现阶段发现的真核生物体内最广泛的RNA表观遗传修饰方式,近年来研究显示,m6A在真核生物间具有较高的保守性,在基因表达及细胞命运调控中发挥着关键作用,且对mRNA的可变剪接、定位、翻译及稳定性有较大影响。现有的m6A修饰检测技术可以较为准确、高效地检测出生物样本中的m6A修饰丰度,并能快速、简便地进行m6A修饰的高通量测序,以及在单碱基分辨率下检测m6A修饰在RNA上的位置。尽管m6A修饰相关调控蛋白对畜禽复杂经济性状的影响近年来已有少量报道,但其中的作用机制仍未得到充分阐明。大量人类及模式生物上的研究表明,m6A修饰相关蛋白能够影响生长发育、繁殖、热应激、炎症及癌症等生物学过程,为探究畜禽m6A修饰参与复杂性状调控机制提供一定的借鉴意义。作者主要从m6A甲基化修饰相关蛋白(甲基转移酶、去甲基化酶及读取蛋白)、m6A检测技术、m6A对哺乳动物复杂性状的调控机制、m6A与其他表观修饰的互作机制等方面进行阐述,为m6A在畜禽遗传育种中的应用提供新的见解。
中图分类号:
史源钧, 米思远, 俞英. m6A表观遗传修饰及其调控机制研究进展[J]. 中国畜牧兽医, 2022, 49(1): 197-207.
SHI Yuanjun, MI Siyuan, YU Ying. Research Progress on m6A Epigenetic Modification and Its Regulation Mechanism[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(1): 197-207.
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