非编码RNA及其在畜禽中的应用研究进展

doi:10.16431/j.cnki.1671-7236.2021.01.026

摘要/Abstract

摘要： 在真核生物基因组转录过程中，除了一些蛋白质编码RNA以外，还有一些不同类型的非编码RNA（non-coding RNA，ncRNA）也参与了复杂生命活动过程的调节。近年来，全转录组测序技术的出现和生物信息学的快速发展极大地促进了人们对ncRNA的研究，ncRNA在生物领域的多个方面具有重要作用，如在人类肿瘤、非肿瘤等方面的疾病治疗，在动物胚胎发育、肌肉生长、脂肪沉积、免疫应答及皮肤毛囊调控等领域都有了很大的进展。作者主要综述了全转录组测序技术、ncRNA分类、主要作用机制和ncRNA在畜禽中的应用，为探究ncRNA在动物中的调控机制提供理论依据。

关键词: 非编码RNA(ncRNA); 全转录组测序; 畜禽; 应用

Abstract: In the process of eukaryotic genome transcription,in addition to some protein coding RNAs,there are some different types of non-coding RNA (ncRNA) also participate in the regulation of complex life processes.In recent years,the emergence of whole transcriptome sequencing technology and the rapid discovery of bioinformatics have greatly promoted the research of ncRNA,revealing the important role of ncRNA in various aspects of the biological field.Including the treatment of tumor and other non tumor diseases in human,the development of embryo,muscle growth,fat deposition,immune response and regulation of skin hair follicle in animals have made great progress.The author mainly introduced the whole genome sequencing technology,the classification of ncRNA,the main mechanism of action and the application of ncRNA in livestock and poultry,it provided a theoretical basis for exploring the regulatory mechanism of ncRNAs in animals.

Key words: non coding RNA (ncRNA); whole transcriptome sequencing; livestock and poultry; application

中图分类号:

Q522

尚方正, 韩文静, 吴志红, 海尔汗, 马荣, 张燕军, 李金泉. 非编码RNA及其在畜禽中的应用研究进展[J]. 中国畜牧兽医, 2021, 48(1): 235-247.

SHANG Fangzheng, HAN Wenjing, WU Zhihong, HAI Erhan, MA Rong, ZHANG Yanjun, LI Jinquan. Research Advance on Application of Non-coding RNA in Livestock and Poultry[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 235-247.

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