丁酸钠对肉鸡肠道形态与消化吸收功能影响的研究进展

doi:10.16431/j.cnki.1671-7236.2021.05.011

摘要/Abstract

摘要： 肠道是肉鸡重要的消化、内分泌及免疫器官，肠道健康主要依赖于营养物质、微生物菌群和肠道黏膜之间的动态平衡。肠道消化吸收功能与肠黏膜上皮细胞的生长及肠道形态结构的完整性直接相关。研究表明，丁酸钠作为能量来源，可刺激肉鸡肠道上皮细胞增殖并改善肠道黏膜形态，促进绒毛生长和肠道组织发育。丁酸钠通过肠道游离脂肪酸受体FFAR2和FFAR3介导肠道内分泌细胞分泌多种激素，促进胃肠黏膜的发育，刺激胃和胰腺分泌消化酶，促进养分消化吸收。丁酸钠是肠道稳态的重要调节因子，可刺激黏蛋白的产生，增加黏液层厚度，降低结肠上皮的通透性，维持肠道完整性和黏膜屏障功能。丁酸钠促进宿主防御肽（HPDs）的合成，抑制肠道内有害菌的增殖，降低内毒素对肠黏膜上皮细胞的损伤。丁酸钠通过抑制NF-κB激酶（IKK）下调促炎症途径，抑制NF-κB的活化，预防肠黏膜炎症发生，进而促进消化吸收和保护肠道健康。综上，丁酸钠具有肠道保护和抗菌作用，可增强肠道完整性，促进营养物质的消化吸收，提高免疫力和抗病力。在饲料工业禁抗的背景下，对抗生素替代品丁酸钠的研究和应用非常重要，作者就丁酸钠对肠道功能的作用机制进行重点阐述，以期为其在肉鸡饲料中替代抗生素提供科学依据。

关键词: 丁酸钠; 肉鸡; 肠道形态; 消化吸收

Abstract: The intestine is an important digestive,endocrine and immune organ of broilers,and intestinal health depends on the dynamic balance between nutrients,microbial flora and intestinal mucosa.Intestinal digestion and absorption are directly related to the growth of intestinal epithelial cells and intestinal morphology integrity.As an energy source,sodium butyrate can stimulate intestinal epithelial cell proliferation,and improve intestinal mucosal morphology in broiler and promote villus growth and intestinal tissue development.Through the intestinal free fatty acid receptors FFAR2 and FFAR3,sodium butyrate mediates the secretion of various hormones from intestinal endocrine cells,promotes gastrointestinal mucosa development,and stimulates the secretion of digestive enzymes from the stomach and pancreas,and promote nutrient digestion and absorption.Sodium butyrate is an essential regulator of intestinal homeostasis,which can stimulate mucin production,increase the thickness of mucus layer,reduce the permeability of colonic epithelium,and maintain intestinal integrity and mucosal barrier function.Sodium butyrate promotes the synthesis of host defense peptides (HPDs),inhibits intestinal harmful bacteria's proliferation,and reduces endotoxin's damage to intestinal epithelial cells.By inhibiting NF-κB kinase (IKK),sodium butyrate can down-regulate the pro-inflammatory pathway,inhibit the activation of NF-κB,prevent intestinal mucosal inflammation,promote digestion and absorption,and protect intestinal health.Therefore,sodium butyrate has intestinal protection and antibacterial effect,enhances intestinal integrity,promote digestion and absorption of nutrients and improves immunity and disease resistance.Under the background of the prohibition of antibiotics in the feed industry,it is very important to study and apply sodium butyrate as an antibiotic substitute.The authors focused on the mechanism of the effect of sodium butyrate on intestinal function,in order to provide a scientific basis for the replacement of antibiotics in broiler feed.

Key words: sodium butyrate; broiler; intestinal morphology; digestion and absorption

中图分类号:

S816.7

李祥, 何金环, 潘春梅, 索江华, 李京. 丁酸钠对肉鸡肠道形态与消化吸收功能影响的研究进展[J]. 中国畜牧兽医, 2021, 48(5): 1603-1612.

LI Xiang, HE Jinhuan, PAN Chunmei, SUO Jianghua, LI Jing. Research Progress on Effect of Sodium Butyrate on Intestinal Morphology, Digestion and Absorption Function of Broilers[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(5): 1603-1612.

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