威尔姆氏瘤基因1对肾脏和性腺发育影响的研究进展

Abstract

Abstract: The Wilms tumor gene 1(WT1) is first found to be inactivated in Wilms toumor. It encodes zinc finger proteins which act as tumor suppressor and play important roles in the development of the genitourinary system and several other tissues.WT1-null mice do not have kidneys and gonads and have abnormal retinas.In addition, WT1 is also required for normal male sex determination in the context of urogenital development. Hence, WT1 is required for both kidney and gonads development. But the mechanisms underlying these phenotypic abnormalities are largely unknown.

Key words:

Wilms tumor gene 1; kidney; gonads

AN Pei-pei, LI Chun-yi. Research Progress on the Effects of Wilms Tumor Gene 1 on the Development of Kidney and Gonads[J]. .

References

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Research Progress on the Effects of Wilms Tumor Gene 1 on the Development of Kidney and Gonads

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