木犀草素对急性汞中毒小鼠血液生化指标、肝脏及肾脏的影响

doi:10.16431/j.cnki.1671-7236.2016.06.016

Abstract

Abstract: To study the effect of luteolin on blood indexes,liver and kidney in mice with acute mercury poisoning,28 mice were randomly divided into four groups:Control group (intraperitoneal injection 0.9% saline),luteolin group (lavage 100 mg/kg luteolin),mercuric chloride group (intraperitoneal injection 4 mg/kg mercury chloride) and mercury chloride+luteolin group (intraperitoneal injection 4 mg/kg mercuric chloride,lavage 100 mg/kg luteolin).The activities of ALT in serum,AST,CREA and BUN contents,blood WBC,RBC,HGB content and GSH and MDA contents of liver tissue were detected.Morphological changes of liver and kidney tissues were observed.The results showed that compared with the control group,the activities of ALT and AST of mercuric chloride group were extremely significantly increased (P < 0.01),serum CREA,BUN,blood WBC and liver tissue MDA contents were significantly increased (P < 0.05) while blood RBC,HGB and liver tissue GSH contents were significantly decreased (P < 0.05).Liver,kidney pathological changes were obviously.Compared with mercuric chloride group,the activities of ALT,AST in serum,CREA,BUN,blood WBC and liver tissue MDA contents of mercuric chloride+luteolin group were significantly decreased (P < 0.05),while blood RBC,HGB and liver tissue GSH contents were significantly elevated (P < 0.05).Liver,kidney pathological changes were attenuated obviously.The poisoning were characterized by inflammation and the occurrence of anemia when acute mercury poisoning occurred,liver and kidney showed different degrees of injury in mice.Luteolin could reduce the toxic effects of acute mercury poisoning on blood,liver and kidney.

Key words: luteolin; mercury poisoning; blood; liver; kidney

CLC Number:

S852.2

TAN Xiao, YANG Da-qian, ZHANG Hai-li, JIANG Jing, CHEN Yan, ZHANG Zhi-gang. Effect of Luteolin on Blood Indexes,Liver and Kidney in Mice with Acute Mercury Poisoning[J]. , 2016, 43(6): 1506-1511.

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Effect of Luteolin on Blood Indexes,Liver and Kidney in Mice with Acute Mercury Poisoning

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