中药复方板青可溶性粉防治鸡传染性支气管炎的效果研究

doi:10.16431/j.cnki.1671-7236.2020.10.038

Abstract

Abstract: The purpose of this study was to study the efficacy and effect of compound Banqing soluble powder in preventing and treating chickens infected with infectious bronchitis virus.The chickens were randomly divided into prevention group,treatment group,Shuanghuanglian control group,Maxing Shigan control group,model control group and blank control group.Among them,the prevention group and the treatment group were divided into high,middle and low dose groups respectively.Except for the blank control group,the prevention group was given drugs through drinking water for 3 consecutive days from 12 days old,and then the 15-day-old chicks were exposed to 0.2 mL infectious bronchitis virus by nasal drip,and the treatment group was given drinking water for 6 days.The number of infected and cured chickens were collected during the experiment,the incidence,protection rate and cure rate were calculated,and the index of immune organs,the ability of lymphocyte proliferation and the levels of cytokines IL-2,IL-4,TNF-α and IFN-α in serum were detected to explore the preventive and therapeutic effect of compound Banqing soluble powder on IBV infected chicks.The results of this experiment showed that the protective rate of compound banqing soluble powder against high dose group could reach 66.67%,and the cure rate of the treatment middle dose group was 83.33%.On the other hand,it increased the immune organ index of infected chicks,after exposure 4 and 10 d,the proliferative capacity of T lymphocytes and B lymphocytes in each administration group was significantly higher than that of the model control group (P<0.05).It could also regulate the levels of IL-2,IL-4,TNF-α and IFN-α in serum to maintain dynamic balance,after the challenge (5 and 11 d),the middle-dose group of IL-4 and IFN-α levels were significantly higher than the model control group (P<0.05).Synthesizing the test data,compound Banqing soluble powder had a good effect on the prevention and treatment of infectious bronchitis,and the therapeutic effect was better than the preventive effect.Among them,the preventive high dose group and the middle dose group were the most effective.

Key words: compound Banqing soluble powder; chicken infectious bronchitis; immune organ index; lymphocytes; cytokines

CLC Number:

S853.31

YAN Yanhua, CHEN Tong, CHEN Zewen, XUE Yang, DU Fangfang, ZHANG Hongying, TONG Chao, WANG Xuebing. Study on the Preventive and Therapeutic Effect of Compound Banqing Soluble Powder on Chicken Infectious Bronchitis[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(10): 3379-3388.

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Study on the Preventive and Therapeutic Effect of Compound Banqing Soluble Powder on Chicken Infectious Bronchitis

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