China Animal Husbandry and Veterinary Medicine ›› 2020, Vol. 47 ›› Issue (1): 267-274.doi: 10.16431/j.cnki.1671-7236.2020.01.031

• Basic Veterinary Medicine • Previous Articles     Next Articles

Comparative Study on Pharmacokinetics of Long-acting Transdermal Agents of Ivermectin and Common Injection in Rabbits

LIU Yingying1, YUE Zhiguang2, WU Ningpeng3, LIU Zhenzhen1, YAN Yaqun1, ZHANG Sumei1, JIAN Fuchun1, ZHANG Longxian1, WANG Rongjun1, NING Changshen1   

  1. 1. College of Animal Husbandry and Veterinary Science, Henan Agricultural University, Zhengzhou 450002, China;
    2. Henan Amgen Biotechnology Co., Ltd., Zhengzhou 450002, China;
    3. Henan Provincial Animal Husbandry Bureau, Zhengzhou 450002, China
  • Received:2019-07-19 Online:2020-01-20 Published:2020-01-17

Abstract: To compare the drug metabolism and efficacy time of ivermectin long-acting transdermal preparation and ordinary ivermectin injection,the study prepared the long-acting transdermal preparation with ivermectin content of 0.5%,1.0% and 1.5% respectively.The pharmacokinetics of ivermectin long-acting transdermal preparation and common ivermectin injection (1.0%) in rabbits with different dosage and the same volume were detected by HPLC,and the data were analyzed by PKSolver pharmacokinetic processing software.The results showed that the t1/2ka of 0.5%,1.0%,1.5% ivermectin long-acting transdermal agent and 1.0% injection were 0.81,0.52,1.02 and 0.12 d,respectively;The Tmax were 1.55,0.97,1.62 and 0.42 d,respectively;The Cmax were 47.36,72.02,115.30,99.53 ng/mL,respectively;The t1/2ke were 3.61,5.92,5.59 and 1.79 d;The MRT were 5.27,7.37,5.13 and 2.16 d,respectively;The AUC were 1 488.70,3 081.98,3 161.20 and 480.00 ng·d/mL,respectively.The effective concentration of long-acting transdermal agent of ivermectin was maintained for 35 d in vivo and 9 d in general injection.The effect of long-acting transdermal agents of ivermectin was confirmed,which could be further studied.

Key words: ivermectin; long-term transdermal agent; pharmacokinetic; HPLC

CLC Number: