益生菌对肠道先天防御反应调节作用的研究进展

doi:10.16431/j.cnki.1671-7236.2017.12.037

Abstract

Abstract:

Probiotics are a kind of living microorganism which can be administered in feed and confer numerous health benefits to animals. Probiotics play a key role in maintaining the microbial balance of gastrointestinal, immunomodulation and pathogen defense, specific probiotics show certain degree of potential to reinforce the integrity of intestinal epithelium and regulate some immune components. The mechanism of probiotic action is an area of interest. Among all possible routes of modulation by probiotics of intestinal mediated defense responses, modulations of intestinal barrier function, innate and adaptive mucosal immune responses as well as signaling pathways are considered to play an important role in the intestinal defense responses against pathogenic bacteria. This review summarizes how probiotic bacteria interact with goblet cell-derived mucins, trefoil factors (TFFs),defensins, Toll-like receptors (TLRs), secretory immunoglobulin A (sIgA), heat shock proteins (HSPs) and P-glycoproteins (P-gp) in the gut to regulate the intestinal innate defense responses,which is regarded as the scientific basis for the future detailed study of benefits of probiotics towards the health of intestine and also dietary intervention against intestinal exposure to pathogens.

Key words: probiotics; intestinal epithelia; innate immunity; immune molecules

CLC Number:

S811.2

ZHANG Man, JIN Xin, TIAN Qiao-zhen, LIU Jiao, WANG Yun-he, ZHANG Zhao-yi, YANG Yin-feng. Advances in Modulation of Intestinal Innate Defense Responses by Probiotic Bacteria[J]. , 2017, 44(12): 3656-3662.

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Advances in Modulation of Intestinal Innate Defense Responses by Probiotic Bacteria

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