迷迭香酸对哮喘小鼠氧化性肺损伤的保护作用

doi:10.16431/j.cnki.1671-7236.2017.12.036

Abstract

Abstract:

In order to evaluate the protective effect of rosmarinic acid on oxidative lung damage in asthmatic mice, in this study, the asthma model was established by sensitizing and challenging female BALB/c mice with ovalbumin (OVA), and some mice were challenged by OVA and H₂O₂ as a positive control of oxidative lung damage. The BALF, lung tissues of mice were harvested 24 h after the final OVA challenge and the number of total cells and eosinophils were measured, ROS,SOD and GSH-Px levels were detected, and pathological changes of lung tissue were observed using HE staining. The results showed that rosmarinic acid significantly reduced the number of total cells and eosinophils in BALF, significantly inhibited the production of ROS in lung tissue and BALF, increased the levels of SOD and GSH-Px, and ameliorated pathological changes of lung tissue. The results suggested that rosmarinic acid could protect oxidative lung damage in asthmatic mice.

Key words: rosmarinic acid; asthma; oxidative lung damage; antioxidation

CLC Number:

R285.5

LIANG Zheng-min, LIAO Xiao-guang, WEN Xue-mei, XU Yang-feng, DENG Xin, YAN Guo-qing, HE Jia-kang. Protective Effects of Rosmarinic Acid on Oxidative Lung Damage in Asthmatic Mice[J]. , 2017, 44(12): 3650-3655.

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Protective Effects of Rosmarinic Acid on Oxidative Lung Damage in Asthmatic Mice

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