肠道微生物-上皮细胞屏障互作的研究进展

doi:10.16431/j.cnki.1671-7236.2017.12.035

Abstract

Abstract:

Intestinal epithelial cells (IECs) are the first line of defense against pathogenic microorganisms of animal organism, which are important component of mucosal mechanical barrier, immune barrier and chemical barrier, they have absorption and barrier double function. In the intestine, there are many kinds of microorganisms. According to its relationship with the host, it is divided into three types of commensal bacteria, conditional pathogenic bacteria and pathogenic bacteria, it plays an important role in the construction of intestinal barrier. Firstly, IECs identify the intestinal microbes by direct or indirect ways, and distinguish their own and non-self, it is immune tolerance to their own substances (such as, commensal bacteria), and produce specific immune response to non-self-substances (pathogenic bacteria). Both of IECs and intestinal commensal bacteria together against pathogens maintain intestinal health. When the pathogenic microorganisms invade the intestine, IECs defense pathogenic microorganisms mainly through extracellular secretions and cell surface mucus layer, and the former largely include mucin, antibacterial molecular and antimicrobial immunoglobulin. The intestinal symbiotic bacteria can resist the pathogenic microorganisms and maintain the normal intestinal mucosal barrier function through the competitive identification sites, the secretion of antimicrobial substances, the increase of mucus secretion, the induction of IECs renewal, proliferation and repair. In the process of resisting invasion of gut microbes, pathogenic microorganisms through their own movement, secretion of toxins and enzymes to destroy the intestinal epithelial barrier, and directly contact with IECs to damage them. So the interaction between IECs and intestinal bacteria maintain the intestinal homeostasis. In this paper, a review is made of the IECs and intestinal microbial structure and functional adaptations, and hope to elaborate the mechanism of intestinal microbial-epithelial cell barrier interaction.

Key words: intestinal epithelial cell (IECs); gut microbes; interaction mechanism

CLC Number:

S852.21

WAN Hua-yun, HU Jun-yi, WANG Zi-xu, CHEN Yao-xing, CAO Jing, DONG Yan-jun, MA Bao-chen, DONG Yu-lan. Research Advance on Intestinal Microbial-epithelial Cell Barrier Interactions[J]. , 2017, 44(12): 3642-3649.

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Research Advance on Intestinal Microbial-epithelial Cell Barrier Interactions

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