β-catenin和BMP2基因在幼龄水貂皮肤中表达的研究

Abstract

Abstract: This experiment was designed to investigate the regularity and significance of β-catenin and BMP2 mRNA expression in skin of young minks. The mRNA expressions of β-catenin and BMP2 in the skin from 0 to 6 weeks old minks were studied by Real-time quantitative PCR relative quantitative method (ΔΔCt). The dorsocentral region of skin samples were collected from three minks per week. The results showed that β-catenin significantly up-regulated at 4 weeks old (P<0.05) and reached the maximum at 5 weeks old (P<0.01), then compared to 5 weeks old,it extremely significantly decreased at 6 weeks old (P<0.01), while the expression of BMP2 mRNA kept stable with weeks increasing (P>0.05). Combined the results of hair follicle histology of young mink, we could conclude that the abundance of β-catenin mRNA was correlated with secondary follicle development. It might be involved in the development of skin and secondary hair follicle in mink, and the abundance of BMP2 did not apparently change at different developmental stages of follicles.

Key words: mink; young; skin; β-catenin; BMP2; gene expression

CLC Number:

WANG Zhuo, LI Guang-yu, YANG Ya-han, ZHANG Tie-tao, ZHANG Hai-hua, SUN Hao-ran, SUN Wei-li. Study on Expression of β-catenin and BMP2 Genes in Skin of Young Minks[J]. , 2014, 41(11): 14-19.

References

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Study on Expression of β-catenin and BMP2 Genes in Skin of Young Minks

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