Abstract: Aleutian mink disease (AMD) is an important infectious disease of mink caused by the Aleutian mink disease virus (AMDV).Further research on AMDV is of great significance for the prevention and control of the disease.The AMDV genome is about 4.8 kb in length and encodes two structural proteins and three non-structural proteins,which play important roles in virus replication,proliferation and host pathogenic process.The replication of AMDV is dependent on metabolically active cells,and in young mink,viral infection of alveolar type Ⅱ cells causes acute lethal pneumonia,while infection of macrophages causes chronic progressive disease such as hypergammaglobulinemia and immune complex-mediated glomerulonephritis in adult mink.In this paper,the pathogenesis of AMDV is described in terms of its receptor pathway of cell invasion,apoptosis induction pathway and viral replication.AMDV is widely prevalent worldwide,and the existing detection methods are mainly serological diagnostic methods and molecular biology diagnostic methods.At present,no safe and effective commercial vaccine against AMDV has been developed,and with the rapid development of biological technology,progress has been made in the development of the inactivated vaccine,DNA vaccine and subunit vaccine.New methods of antiviral such as screening of AMDV-tolerant mink,improving mink immunity and targeted aptamer technology provide new ideas for the prevention and control of AMD.This article summarizes the research progress of AMDV at home and abroad in recent years in terms of AMDV encoding protein function,viral cell tropism and replication,clinical manifestations and pathogenesis,diagnostic methods and control measures,aiming to provide a reference for the development of safe and effective vaccines and drugs for the prevention and control of AMDV.

Key words: Aleutian mink disease virus (AMDV); molecular proteins; cell tropism; pathogenic mechanism; prevention and treatment