黄芪多糖的药理作用及其在仔猪疾病防治中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2018.10.030

Abstract

Abstract:

Astragali Radix is a Chinese herbal medicine which is used for both medicine and food,Astragalus polysaccharides is the most important natural active ingredients which has functions of improving immunity and antioxidant ability and intestinal microecology,and has the capability of anti-microbial and anti-virus without drug resistance,of which immune regulation is the most prominent.Numerous studies have demonstrated that Astragalus polysaccharides have significant immunomodulatory effect in vivo and in vitro.The authors introduced the regulatory effect of Astragalus polysaccharide on immune related genes,its role in organ immunity,cellular immunity,cytokines and intracellular messenger substances,cardiovascular system immunity,antibacterial immunity and antiviral immunity,and summarized its application used as immune adjuvant in CSF,PCVD,FMD,PRRS and MPS in the latest research progress.At present,most researches are limited to the structure of Astragalus polysaccharide,which is mainly used as immune adjuvant and animal feed additive,and its application range is narrow which lacks deep research and development.In the future,we should strengthen the separation and purification of low molecular weight Astragalus polysaccharide,explore its structure characteristics and immune regulation of the structure-activity relationship to improve its curative effect,promote its clinical application.

Key words: Astragalus polysaccharides; pharmacologic action; pig; prevention and treatment of diseases

CLC Number:

S828

ZHENG Xinxin, LI Fukuan, PAN Zhangyuan, LV Shenjin, WANG Hui. Research Progress on Pharmacological Action of Astragalus Polysaccharide and Its Application in Piglet Disease Prevention and Treatment[J]. , 2018, 45(10): 2918-2926.

References

[1] 单俊杰,王易,翁颖琦,等.黄芪毛状根多糖与黄芪多糖化学组成及免疫活性的比较[J].中草药,2002,33(12):1096-1099.SHAN J J,WANG Y,WENG Y Q,et al.Comparing compositions and immunoactivities of polysaccharide in hair root of Astragalus membranceus and cultivated A.membranaceus[J].Chinese Traditional and Herbal Drugs,2002,33(12):1096-1099.(in Chinese)
[2] 高旭,李丽芬,刘斌钰.黄芪多糖对小鼠免疫功能影响的实验研究[J].山西大同大学学报(自然科学版),2010,26(14):42-44.GAO X,LI L F,LIU B Y.The experimental study on the effect of APS on immunologic function in mice[J].Journal of Shanxi Datong University (Natural Science Edition),2010,26(14):42-44.(in Chinese)
[3] 胡晓燕,郝选明.黄芪多糖对运动性免疫抑制的调理[J].广州体育学院报,2011,31(1):85-88.HU X Y,HAO X M.Modulation of Astragalus polysaccharide on exercise-induced immune suppression[J].Journal of Guangzhou Sport University,2011,31(1):85-88.(in Chinese)
[4] 李钦,胡继宏,高博,等.黄芪多糖在免疫调节方面的最新研究进展[J].中国实验方剂学杂志,2017,23(2):199-206.LI Q,HU J H,GAO B,et al.Advances on immunoregulation effect of Astragalus polysaccharides[J].Chinese Journal of Experimental Medical Formulae,2017,23(2):199-206.(in Chinese)
[5] JACKUTË J,ZEMAITIS M,PRANYS D,et al.Distribution of CD4⁺ and CD8⁺ T cell in tumor islets and stroma from patients with non-small cell lung cancer in association with COP D and smoking[J].Medicina,2015,51(5):263-271.
[6] SONG M M,FANG S,TANAKA S,et al.Effects of arsenic disulfide on proliferation,cytokine production,and frequencies of CD4⁺,CD8⁺,and regulatory T cells in mitogen-activated human peripheral blood mononuclear cells[J].International Immunopharmacology,2015,29(2):832-838.
[7] CHEN W,LI Y M,YU M H.Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activa-tion[J].Journal of Diabetes and Its Complications,2010,24(3):199-208.
[8] SHAO B M,XU W,DAI H,et al.A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus,a Chinese medicinal herb[J].Biochemical and Biophysical Research Communications,2004,320(4):1103-1111.
[9] 杜红红,张波.黄芪多糖在兽医临床的应用[J].中国畜牧兽医文摘,2012,28(8):195.DU H H,ZHANG B.Application of Astragalus polysaccharide in veterinary clinic[J].Chinese Abstracts of Animal Husbandry and Veterinary Medicine,2012,28(8):195.(in Chinese)
[10] 姜琛璐,汤承,骞宇,等.黄芪多糖免疫调节作用研究进展[J].食品科学,2013,34(11):327-332.JIANG C L,TANG C,QIAN Y,et al.Immunoregulation effect of Astragalus polysaccharides[J].Food Science,2013,34(11):327-332.(in Chinese)
[11] 翁玲,刘彦,刘学英,等.黄芪多糖粉针剂对小鼠脾细胞分泌细胞因子及NK杀伤能力的影响[J].中华中医药学刊,2003,21(9):1522-1524.WENG L,LIU Y,LIU X Y,et al.Effect of Astragalus polysaccharide powder on secretion cytokines and NK killing ability of mouse spleen cells[J].Chinese Archives of Traditional Chinese Medicine,2003,21(9):1522-1524.(in Chinese)
[12] LIU Q Y,YAO Y M,ZHANG S W,et al.Astragalus polysaccharides regulate T cell-mediated immunity via CD11c (high) CD45RB (low) DCs in vitro[J].Journal of Ethnopharmacology,2011,136(3):457-464.
[13] SUN Y,JIN L,WANG T,et al.Polysaccharides from Astragalus membranaceus promote phagocytosis and superoxide anion (O2-) production by coelomocytes from sea cucumber Apostiches japonicus in vitro[J].Comparative Biochemistry and Physiology Part C:Toxicology and Pharmacology,2008,147(3):293-298.
[14] KOPSTAD G,ELGSAETER A.Theoretical analysis of specimen cooling rate during impact freezing and liquid-jet freezing of freeze-etch specimens[J].Biophysical Journal,1982,40(2):163-170.
[15] BALD W B.On crystal size and cooling rate[J].Journal of Microscopy,1986,143(1):89-102.
[16] YANG Y Z,JIN P Y,GÚO Q,et al.Effect of Astragalus membranaceus on natural killer cell activity and induction of alpha-and gamma-interferon inpatients with Coxsackie B viral myocarditis[J].Chinese Journal of Cardiology,1998,16(6):337.
[17] SHAO P,ZHAO L H,CHEN Z,et al.Regulation on maturation and function of dendritic cells by Astragalus mongolicins polysaccharides[J].International Immunopharmacology,2006,6(7):1161-1166.
[18] TÖRÖK K,DEZSÖ B,BENCSIK A,et al.Complement receptor type 1(CR1/CD35) expressed on activated human CD4⁺ T cells contributes to generation of regulatory T cells[J].Immunology Letters,2015,164(2):117-124.
[19] LI H Q,LIOYD R J,WANG J D.Effect of Astragalus polysaccharides on erythrocyte immune adherence of chickens inoculated with infectious bursal disease virus[J].Agricultural Sciences in China,2007,6(11):1402-1408.
[20] SÁNCHEZ-CORDÍN P J,PÉREZ DE DIEGOB A C,GÍMEZ-VILLAMANDOS J C,et al.Comparative analysis of cellular immune responses and cytokine levels in sheep experimentally infected with bluetongue virus serotype 1 and 8[J].Veterinary Microbiology,2015,177(1-2):95-105.
[21] LORENZ T K,HEIMAN J R,DEMAS G E.Sexual activity modulates shifts in TH1/TH2 cytokine profile across the menstrual cycle:An observational study[J].Fertility and Sterility,2015,104(6):1513-1521.
[22] LI R,CHEN W C,WANG W P,et al.Antioxidant activity of Astragalus polysaccharides and antitumor activity of the polysaccharides and siRNA[J].Carbohydrate Polymers,2010,82(2):240-244.
[23] ZHANG X,YAO K,REN L,et al.Protective effect of Astragalus polysaccharide on endothelial progenitor cells injured by thrombin[J].International Journal of Biological Macromolecules,2016,82:711-718.
[24] 颜爱,李波,李润成,等.香菇多糖和黄芪多糖对免疫抑制小鼠免疫功能调节的研究[J].中国免疫学杂志,2012,28(11):999-1001.YAN A,LI B,LI R C,et al.Effect of Lentinan and Astragalus polysaccharide on immunological function in immunosuppressed mice[J].Journal of Chinese Immunology,2012,28(11):999-1001.(in Chinese)
[25] ZHENG Y J,ZHOU B,SONG Z F,et al.Study of Astragalus mongolicins polysaccharides on endothelial cells permeability induced by HMGB[J].Carbohydrate Polymers,2013,92(1):934-941.
[26] 樊英,王淑娴,叶海斌,等.黄芪多糖对仿刺参非特异性免疫功能的影响[J].水产科学,2010,29(6):321-324.FAN Y,WANG S X,YE H B,et al.Effects of polysaccharides from Astragalus membranaceus on non-specific immune in sea cucumber Apostichopus japonicus[J].Fisheries Science,2010,29(6):321-324.(in Chinese)
[27] 梁丽娟,屠腾飞,赵奎军.黄芪多糖的药理作用研究进展[J].中国药房,2010,33(43):4113-4116.LIANG L J,TU T F,ZHAO K J.Research progress on pharmacological action of Astragalus polysaccharide[J].China Pharmacy,2010,33(43):4113-4116.(in Chinese)
[28] 朱丹.黄芪多糖对人心脏微血管内皮细胞缺血再灌注损伤影响的研究[D].北京:北京中医药大学,2009.ZHU D.Study on the influence of Astragalus polysaccharide on ischemia and reperfusion injury in human heart microvascular endothelial cells[D].Beijing:Beijing University of Chinese Medicine,2009.(in Chinese)
[29] 陈立新,朱海燕,朱陵群,等.黄芪多糖对人心脏微血管内皮细胞增殖及再灌注后内皮细胞与中性粒细胞黏附的影响[J].中国组织工程研究,2007,11(27):5382-5386.CHEN L X,ZHU H Y,ZHU L Q,et al.Effects of Astragalus polysaccharides on the proliferation of human cardiac microvascular endothelial cells and adherent to polymorphonuclear neutrophils after reperfusion injury[J].Chinese Journal of Tissue Engineering Research,2007,11(27):5382-5386.(in Chinese)
[30] DU X,ZHAO B,LI J,et al.Astragalus polysaccharides enhance immune responses of HBV DNA vaccination via promoting the dendritic cell maturation and suppressing Treg frequency in mice[J].International Immunopharmacology,2012,14(4):463.
[31] ZHANG N W,LI J F,HU Y X,et al.Effects of Astragalus polysaccharide on the immune response to foot-and-mouth disease vaccine in mice[J].Carbohydrate Polymers,2010,82(3):680-686.
[32] 朱辉,沈志强,王振勇,等.黄芪多糖注射液对猪瘟耐热保护剂活疫苗在兔体内免疫效果的影响[J].中国畜牧兽医,2011,38(7):66-70.ZHU H,SHEN Z Q,WANG Z Y,et al.Effects of APS injection to activated thermostabilized vaccine of swine fever in rabbit[J].China Animal Husbandry & Veterinary Medicine,2011,38(7):66-70.(in Chinese)
[33] 赵娟,刘凤华,邱河辉,等.黄芪多糖对PCV2阳性猪外周血免疫细胞及相关细胞因子的影响[J].中国兽医杂志,2010,46(3):3-5.ZHAO J,LIU F H,QIU H H,et al.Effects of Astragalus polysaccharide on peripheral blood immunocytes and related cytokines in PCV2 antigen-antibody positive pigs[J].Chinese Journal of Veterinary Medicine,2010,46(3):3-5.(in Chinese)
[34] 毛晓峰.黄芪多糖影响断奶仔猪免疫功能及其作用机理的研究[D].北京:中国农业大学,2004.MAO X F.Study on the effects of Astragalus polysaccharide on immune function and its mechanism of weaning piglets[D].Beijing:China Agricultural University,2004.(in Chinese)
[35] 任志华,王婵,邓俊良,等.中药组方对腹腔注射大肠杆菌小鼠血清Th17、Treg型细胞因子的影响[J].中国兽医学报,2017,37(12):2378-2383.REN Z H,WANG C,DENG J L,et al.Effect of Chinese herbal compound precondition on Th17/Treg-related serum cytokines of mice[J].Chinese Journal of Veterinary Science,2017,37(12):2378-2383.(in Chinese)
[36] WAN J,GE X,LIU B,et al.Effect of dietary vitamin C on non-specific immunity and mRNA expression of three heat shock proteins (HSPs) in juvenile Megalodrama amblycephala under pH stress[J].Aquaculture,2014,434:325-333.
[37] LIU L,SHEN J,ZHAO C,et al.Dietary Astragalus polysaccharide alleviated immunological stress in broilers exposed to lipopolysaccharide[J].International Journal of Biological Macromolecules,2015,72:624-632.
[38] LI J,ZHONG Y,LI H,et al.Enhancement of Astragalus polysaccharide on the immune responses in pigs inoculated with foot-and-mouth disease virus vaccine[J].International Journal of Biological Macromolecules,2011,49(3):362-368.
[39] YUAN C T,PAN X P,GONG Y,et al.Effects of Astragalus polysaccharides (APS) on the expression of immune response genes in head kidney,gill and spleen of the common carp,Cyprinids carpio L.[J].International Immunopharmacology,2008,8(1):51-58.
[40] LEE Y S,HAN O Y,PARK C W,et al.Pro-inflammatory cytokine gene expression and nitric oxide regulation of aqueous extracted Astragali radix in RAW 264.7 macrophage cells[J].Journal of Ethnopharmacology,2005,100(3):289-294.
[41] LEE K Y,JEON Y J.Macrophage activation by polysaccharide isolated from Astragalus membranous[J].International Immunopharmacology,2005,5(7-8):1225-1233.
[42] YANG M,QIAN X H,ZHAO D H,et al.Effects of Astragalus polysaccharide on the erythroid lineage and microarray analysis in K562 cells[J].Journal of Ethnopharmacology,2010,127(2):242-250.
[43] YANG X,HUANG S,CHEN J,et al.Evaluation of the adjuvant properties of Astragalus membranceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models[J].Vaccine,2010,28(3):737-743.
[44] 谢荣华,范久波,舒衡平.黄芪多糖、香菇多糖增强弓形虫wx2b4a表位疫苗免疫小鼠的保护作用[J].中国人兽共患病学报,2015,31(8):724-727.XIE R H,FAN J B,SHU H P.Enhancement of epitope vaccines from wx2b4a of Toxoplasma gondii potency using Astragalan and Lentinan in mice[J].Chinese Journal of Zoonoses,2015,31(8):724-727.(in Chinese)
[45] 鲁路.黄芪多糖对地塞米松和过氧化氢诱导骨骼肌细胞损伤的改善作用[D].广州:南方医科大学,2014.LU L.The effect of Astragalus polysaccharide on the improvement of skeletal muscle cell injury induced by dexamethasone and hydrogen peroxide[D].Guangzhou:Southern Medical University,2014.(in Chinese)
[46] 李锐.CD40信号调控胃癌免疫编辑的作用及机制[D].苏州:苏州大学,2011LI R.The regulation effects and mechanisms of CD40 signal on the immunoediting of human gastric cancer[D].Suzhou:Suzhou University,2011.(in Chinese)
[47] 梁永祺.黄芪多糖对EAhy.926细胞的抗氧化作用及抗炎作用[D].广州:南方医科大学,2013.LIANG Y Q.The antioxidation and anti-inflammatory effects of Astragalus polysaccharide on EAhy.926 cells[D].Guangzhou:Southern Medical University,2013.(in Chinese)
[48] 杨敏.黄芪诱导K562细胞红系分化有效成分初筛及基因表达谱分析[D].广州:南方医科大学,2008.YANG M.Analysis of the initial screening and gene expression profile of the effective components of K562 cell red line[D].Guangzhou:Southern Medical University,2008.(in Chinese)
[49] 杜继红,高亚军,王海良,等.黄芪多糖粉对猪瘟疫苗免疫效果及生产性能的影响[J].中国畜牧杂志,2013,49(22):65-68.DU J H,GAO Y J,WANG H L,et al.Effect of Astragalus polysaccharide powder on the immune effect and production performance of swine fever[J].Chinese Journal of Animal Science,2013,49(22):65-68.(in Chinese)
[50] ZHUGE Z Y,ZHU Y H,LIU P Q,et al.Effects of Astragalus polysaccharide on immune respones of porcine pbmc stimulated with PRRSV or CSFV[J].PLoS One,2012,7(1):378.
[51] 黄德尚,郭爱珍.黄芪多糖佐剂对猪瘟疫苗免疫效果的影响[J].中国畜牧兽医,2011,38(6):189-192.HUANG D S,GUO A Z.Effect of Astragalus polysaccharide adjuvant on the immune effect of swine fever[J].China Animal Husbandry &Veterinary Medicine,2011,38(6):189-192.(in Chinese)
[52] 孙加节,蒋勇,习欠云,等.人参复合多糖提高猪圆环病毒疫苗免疫效果的研究[J].中国预防兽医学报,2016,38(9):734-738.SUN J J,JIANG Y,XI Q Y,et al.Ginseng polysaccharides complex enhances immune response to porcine circovirus in piglets[J].Chinese Journal of Preventive Veterinary Medicine,2016,38(9):734-738.(in Chinese)
[53] 李志娟.Pcv2分离株增殖特性研究及板蓝根多糖、黄芪多糖对pcv2体外复制的影响[D].郑州:河南农业大学,2011.LI Z J.Study on the proliferation characteristics of Pcv2 isolates and the effects of polysaccharide and Astragalus polysaccharide on the replication of Pcv2 in vitro[D].Zhengzhou:Henan Agricultural University,2011.(in Chinese)
[54] 武彩虹,蒋春茂,李玲,等.3种中药活性成分对猪圆环病毒2型疫苗免疫效果的影响[J].中国预防兽医学报,2017,39(8):611-615.WU C H,JIANG C M,LI L,et al.The influence of three active ingredients of traditional Chinese medicine on immune effect of PCV2 vaccine[J].Chinese Journal of Preventive Veterinary Medicine,2017,39(8):611-615.(in Chinese)
[55] YOON K J,WU L L,ZIMMERMAN J J,et al.Antibody-dependent enhancement (ADE) of porcine reproductive and respiratory syndrome virus (PRRSV) infection in pigs[J].Viral Immunology,1996,9(1):51-63.
[56] 邵珊,王贵平,李春玲,等.黄芪多糖和白花蛇草多糖对猪繁殖与呼吸综合征灭活疫苗免疫猪T细胞亚群及抗体水平的影响[J].中国兽医学报,2011,31(8):1196-1199.SHAO S,WANG G P,LI C L,et al.Effects of APS and OPS on T subpopulations in the immune response to porcine reproductive and respiratory syndrome inactived virus vaccine[J].Chinese Journal of Veterinary Science,2011,31(8):1196-1199.(in Chinese)
[57] 刘樱,丁度伟,高求炜,等.3种中药物及其提取物体外抗猪繁殖与呼吸综合征病毒作用的研究[J].中国畜牧兽医,2016,43(10):2730-2745.LIU Y,DING D W,GAO Q W,et al.Antiviral effects of three Chinese herbal medicine and their polysaccharides on porcine reproductive and respiratory syndrome virus (PRRSV) in vitro[J].China Animal Husbandry & Veterinary Medicine,2016,43(10):2730-2745.(in Chinese)
[58] 张红英,崔保安,王学兵,等.2种植物多糖对PRRSV灭活疫苗免疫猪抗体及T淋巴细胞亚群的影响[J].湖南农业大学学报(自然科学版),2010,36(2):210-214.ZHANG H Y,CUI B A,WANG X B,et al.Effects of two polysaccharides on T subpopulations and antibody in the immune response to PRRSV killed virus vaccine[J].Journal of Hunan Agricultural University (Natural Science Edition),2010,36(2):210-214.(in Chinese)
[59] PENG J,YUAN Y,SHEN S,et al.Immunopotentiation of four natural adjuvants co-administered with a highly pathogenic porcine reproductive and respiratory syndrome virus glycoprotein 5 subunit[J].Virus Gene,2016,52(2):261-269.
[60] 封海波,樊静,刘娟,等.4种多糖对口蹄疫疫苗免疫反应的影响[J].西南大学学报(自然科学版),2013,35(11):27-36.FENG H B,FAN J,LIU J,et al.Effect of polysaccharide on immune effect of foot-and-mouth disease vaccine[J].Journal of Southwest University (Natural Science Edition),2013,35(11):27-36.(in Chinese)
[61] 李任军,马艳芬,卢一松,等.口服黄芪多糖增强肠道黏膜免疫及其对口蹄疫疫苗免疫的影响[J].中国兽医学报,2017,37(3):491-496.LI R J,MA Y F,LU Y S,et al.Enhancement of the gut mucosal immunity and immune response to the foot-and-mouth disease vaccine by oral administration of Astragalus polysaccharide[J].Chinese Journal of Veterinary Science,2017,37(3):491-496.(in Chinese)
[62] LI R,SAKWIWATKUL K,YUTAO L,et al.Enhancement of the immune responses to vaccination against foot-and mouth disese in mice by oral administration of an extract made from Rhizome Atractylodis Macrocephalae (RAM)[J].Vaccine,2009,27(15):2094-2098.
[63] MAES D,SEGALES J,MEYNS T,et al.Control of Mycoplasma hyopneumonia infections in pigs[J].Animal Science Abroad,2008,126(4):297-309.
[64] 白吉庆,王小平,贺新怀,等.中药多糖的免疫佐剂作用[J].陕西中医学院学报,2005,28(4):64-65.BAI J Q,WANG X P,HE X H,et al.Immune adjuvant effect of polysaccharide in traditional Chinese medicine[J].Journal of Shaanxi University of Chinese Medicine,2005,28(4):64-65.(in Chinese)
[65] LIN Y,TAN D,KAN Q,et al.The protective effect of naringenin on airway remodeling after Mycoplasma pneumoniae infection by inhibiting autophagy-mediated lung inflammation and fibrosis[J].Mediators of Inflammation,2018,7:1-10.
[66] 熊祺琰,范志鹏,甘源,等.几种佐剂对肌肉注射猪支原体肺炎活疫苗免疫刺激能力的增强作用研究[J].中国畜牧兽医,2011,38(10):163-168.XIONG Q Y,FAN Z P,GAN Y,et al.Study on the effect of several adjuvants on the immune stimulation of Mycoplasma pneumoniae in muscle injection[J].China Animal Husbandry & Veterinary Medicine,2011,38(10):163-168.(in Chinese)
[67] XIONG Q Y,WEI Y N,XIE H D et al.Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation[J].Vaccine,2014,32(27):3445-3451.
[68] YANG S J,LEE S Y,LEE H N,et al.Adjuvant effect of polysaccharides from above ground parts of Astragalus membranceus[J].Korean Journal of Medicinal Crop Science,2016,24(5):408-419.

Research Progress on Pharmacological Action of Astragalus Polysaccharide and Its Application in Piglet Disease Prevention and Treatment

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	WEI Mingbang, BIANBA Qiongda, XIAO Qingqing, DUAN Mengqi, CHAMBA Yangzom, SHANG Peng. Cloning,Bioinformatics and Expression Analysis of CDKN1B Gene in Tibetan Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2196-2206.
[2]	ZHANG Fangwei, ZHANG Qi, LEI Liangliang, SUN Wusheng, ZHANG Di, ZHANG Yunpeng, ZHANG Jingbo, WANG Xiuquan, ZHANG Jing, ZHANG Shumin. Polymorphism of HBEGF Gene and Its Association with Reproductive Traits in Songliao Black Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2370-2379.
[3]	PAN Pengcheng, LEI Zongquan, LI Xian, HU Xiangyun, QIN Qiantao, QIN Zhaoxian, GUAN Zhihui, CHEN Baojian, XIE Bingkun. Bioinformatics Analysis,Eukaryotic Expression Vector Construction and Tissue Expression of MYL2 Gene in Luchuan Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1796-1806.
[4]	OUYANG Kun, WEI Limin, SUN Ruiping, XIE Yali, QI Qi, LI Xiang, LIU Quanwei, CHAO Zhe, ZHANG Yongliang, CHEN Ting. Effects of Curcumin on Growth Performance,Feed Apparent Digestibility and Serum Biochemical Indexes in Hainan Tunchang Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1867-1875.
[5]	WU Jingxuan, SUN Zheng, MA Xuelian, ZHANG Liyang, LIAO Xiudong, LUO Xugang, LI Sufen, LYU Lin. A Survey on Magnesium Contents in Feed Resources for Livestock and Poultry in China [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1888-1898.
[6]	WANG Zeping, WANG Feifei, ZHANG Ruiming, FU Yanfeng, ZHAO Weimin, DAI Chaohui, CHENG Jinhua, LIAO Chao, LI Hui. Analysis on Polymorphism of SLA-1 Gene and Its Disease Resistance Potential in Suzi Pig [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1918-1927.
[7]	LIU Hongrun, ZHU Siran, FENG Lingli, ZHANG Kun, YAN Gang, WANG Yubin, ZHANG Shuai, JIANG Shan, XU Di, LAN Ganqiu, LIANG Jing. Cloning,Bioinformatics Analysis and Tissue Expression Localization of CDO1 Gene in Large White Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1352-1363.
[8]	YAO Kang, CAO Shuting, JIANG Zongyong, WANG Li. The Research Progress of Lysine Application and Requirement in Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1364-1374.
[9]	ZHANG Rui, MU Chunyu, TANG Qingping, BU Zhu, YANG Mingjun, XIA Aiping, YANG Xiaoming. Polymorphism of GnIH Gene and Its Correlation with Egg-laying Traits in Pigeons [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1412-1421.
[10]	ZHANG Fangwei, ZHANG Qi, ZHANG Yunpeng, LI Xin, ZHANG Jingbo, ZHANG Shumin, YU Yongsheng. Polymorphism of FOXA2 Gene Exon 3 and Its Association with Reproductive Traits in Songliao Black Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1444-1451.
[11]	TAN Yuancheng, LUO Hualun, ZHANG Yiyu, YANG Suan, WANG Yingtong, WANG Chunyuan. Polymorphism of MyoG Gene and Its Association with Body Size and Meat Traits in White Feather King Pigeons [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1461-1471.
[12]	HAN Dayong, ZHOU Chunbao, NI Ligang, CHEN Zhangyan, ZHAO Jinming. Genetic Diversity of mtDNA D-loop Sequence in Sujiang Pig [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1472-1479.
[13]	YANG Zhi, YU Jiaxin, YANG Linfu, WANG Kang, LI Guanzong, DUAN Gang, YANG Fumei, LIU Zhiqi, ZHOU Ke, HE Jun, DAI Feiyan. Study on the Therapeutic Effect of Modified Sini Decoction on Piglet Diarrhea [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1707-1717.
[14]	CHANG Yitong, ZHANG Wei, PENG Yinglin, CHEN Chen. Evolutionary Analysis,Target Gene Prediction and Tissue Expression Analysis of miR-192 [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 882-892.
[15]	LIU Zhen, ZHOU Xueqin, XU Fei, LI Zhefeng, SUN Hanxue, LI Guoqin, TAO Zhengrong, GUAN Mei, ZHENG Qiang, DIAO Xinping, LU Lizhi. Effects of Coated Sodium Butyrate on Growing Performance,Slaughter Performance, Immune Organ Index and Digestive Enzyme Activity of Breeding Pigeons and Squabs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 998-1006.